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Tablets

Tablets. Lecturer: dr. Asmaa abdelaziz Mohamed Faculty of pharamcay Ibn hayan University. General Introduction. Tablets is defined as a compressed solid dosage form containing medicaments with or without excipients Role in therapy

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Tablets

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  1. Tablets Lecturer: dr. Asmaa abdelaziz Mohamed Faculty of pharamcay Ibn hayan University 1

  2. General Introduction • Tablets is defined as a compressed solid dosage form containing medicaments with or without excipients Role in therapy Oral solid forms are preferred class of product because of the following: • Accurate dose • Less expensive to ship without breakage or leakage • Bitter taste could be masked by coating • Portable • More stable chemically and physically 2

  3. Advantages advantages • Greatest dose precision and least variability • the lowest cost • the lightest and most compact of all oral dosage forms • easy to scale up in production • convenience in packaging, shipping and dispensing • portability • ease of administration • Sustained release product is possible by enteric coating. 3

  4. disadvantages • 1-some drugs resist compression into tab because of its amorphous nature or low density character • 2-drugs with poor wettability, slow dissolution may be difficult to formulate • 3- bitter testing drugs or drugs with objectionable odour or drugs  that are sensitive to oxygen may require encapsulation or coating.  In such cases, capsule may offer the best and lowest cost.  • 4-Difficult to swallow in case of children and unconscious patients. 4

  5. Challenges in Formulation and manufacture • difficulty in achieving good bioavaiability in case of drugs with poor wetting and slow dissolution • difficulty of compaction for amorphous drugs 5

  6. Evaluation • 1- General Appearance • 2- Size & Shape • 3-Unique identification marking 6

  7. Evaluation • 4-Organoleptic properties • 5-Weight variation • 6-Friability • 7-Hardness • 3-Unique identification marking • 4-Organoleptic properties • 5-Weight variation • 6-Friability • 7-Hardness • 8-Disintegrationtime: • 9-Dissolution rate: • 10-Content Uniformity Test 7

  8. Evaluation • 4-Organoleptic properties • 5-Weight variation • 6-Friability • 7-Hardness • 3-Unique identification marking • 4-Organoleptic properties • 5-Weight variation • 6-Friability • 7-Hardness • 8-Disintegrationtime: • 9-Dissolution rate: • 10-Content Uniformity Test 8

  9. Evaluation • 8-Disintegration time: Tablets into smaller particles or granules • 3-Unique identification marking • 4-Organoleptic properties • 5-Weight variation • 6-Friability • 7-Hardness • 8-Disintegrationtime: • 9-Dissolution rate: • 10-Content Uniformity Test 9

  10. Evaluation • 9-Dissolution rate: It is the dissolved percent of drug per time • 3-Unique identification marking • 4-Organoleptic properties • 5-Weight variation • 6-Friability • 7-Hardness • 8-Disintegrationtime: • 9-Dissolution rate: • 10-Content Uniformity Test 10

  11. EVALUATION SINKERS Mesh Basket Sinker, With Lid 10- Content Uniformity Test WIRE HELIX 11

  12. Thank you

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