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WPI Repository CFS Subjects with Cancer

Explore the relationship between XMRV status, RNaseL genetic variation, and disease progression in comorbid cases of Chronic Fatigue Syndrome and Mantle Cell Lymphoma. This study investigates potential links between XMRV infection, immune dysfunction, and clinical outcomes.

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WPI Repository CFS Subjects with Cancer

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  1. XMRV status determined by the WPI since the submission to Science. WPI Repository CFS Subjects with Cancer XMRV status determined by the WPI since the submission to Science.

  2. 1988- seen at NIH for CFS 1998- Splenectomy to decrease aggressiveness. 2000- seen at NIH for mantle cell lymphoma. Given Rituxan and Velcade 2004- BMT with adult stem cells 2008- Blast crisis MCL…. death WPI-1125 CFS Diagnosis One Decade Prior to MCL • 1988---Seen at NIH for CFS • 1998---Splenectomy to decrease aggressiveness. • 2000---Seen at NIH for mantle cell lymphoma. Given Rituxan and Velcade • 2004---BMT with adult stem cells • 2008---Blast crisis MCL … death MCL cell line developed 2008

  3. Relationship between RNaseL variant genotype and XMRV expression in CFS patients Neither XMRV infection nor a diagnosis of CFS correlate to RNase L genetic variation R462Q

  4. Dysfunction of Natural Killer Activity in a Family with Chronic Fatigue Syndrome

  5. Relative time-scale of the virological and immunological events during XMRV infection Hypothesis of XMRV disease progression: NK dysregulation Relative time-scale of the virological and immunological events during XMRV infection CFS develops Env antigen

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