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ACROPOLIS Jacob van Klaveren

ACROPOLIS Jacob van Klaveren. Contents. History and starting point Aims of ACROPOLIS Main overview (WPs) Project organisation. Starting point for ACROPOLIS. An electronic platform for pan-European exposure modelling as created in SAFE FOODs

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ACROPOLIS Jacob van Klaveren

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  1. ACROPOLISJacob van Klaveren

  2. Contents • History and starting point • Aims of ACROPOLIS • Main overview (WPs) • Project organisation Jacob van Klaveren ACROPOLIS kick-off meeting

  3. Starting point for ACROPOLIS • An electronic platform for pan-European exposure modelling as created in SAFE FOODs • Existing models like EuroPOEM, CONSEXPO, MCRA, IPRA • EFSA opinions on cumulative risk assessment Jacob van Klaveren ACROPOLIS kick-off meeting

  4. Aims of ACROPOLIS • Improve cumulative exposure and hazard assessment • Create new models for aggregated exposure assessment • Setting up new toxicological testing for identifying synergistic effects • To integrate cumulative and aggregated risk models • Improve understanding of methodology of different stakeholders Jacob van Klaveren ACROPOLIS kick-off meeting

  5. E-platform of databases (food and residue) SE CZ UK IT NL FR MCRA-software Jacob van Klaveren ACROPOLIS kick-off meeting

  6. van der Voet & Slob (2007) Toxicological BMD modeling • Critical effect dose • Number of experiments • EFSA opinion BMD modeling Jacob van Klaveren ACROPOLIS kick-off meeting

  7. Aggregated exposure assessment • Combine leading models in Europe(MCRA, EUROPOEM, ConsEXPO) • Case studies with two or more different routes of exposure • Validation of the model Jacob van Klaveren ACROPOLIS kick-off meeting

  8. Mixtures and internal does Jacob van Klaveren ACROPOLIS kick-off meeting

  9. Model and software development Internet compatible model and data • Test and justify underlying assumptions • Scientific sound • Reproducible and transparent (reference manual MCRA openly available) • Include quantitative uncertainty analyses • Data in connection with model available for stakeholders (including industry). Not the raw data. Jacob van Klaveren ACROPOLIS kick-off meeting

  10. Risk based on Margin of Exposure Be aware that safety factors are also modelled! Jacob van Klaveren ACROPOLIS kick-off meeting

  11. Dissemination • Training • Stakeholder conferences • Website and folders • Scientific paper on stakeholders attitudes towards cumulative and aggregated exposure levels Jacob van Klaveren ACROPOLIS kick-off meeting

  12. Stakeholders • Industry • Regulators • EFSA and risk assessors at national level • Risk Management Jacob van Klaveren ACROPOLIS kick-off meeting

  13. ACROPOLIS PROJECT STRUCTURE Jacob van Klaveren ACROPOLIS kick-off meeting

  14. External advisory board EFSA (Luc Mohimont) DG Sanco (Bas Drukker) EPA (D. Miller will be asked) Coordinator • Further elaboration on case studies • Overview needs of DG Sanco (risk managers) • Fine-tune research needs of EFSA Jacob van Klaveren ACROPOLIS kick-off meeting

  15. Scientific Advisory Board WHO, FAO, experts (dr. C. Harris, prof A. Boobis, prof W. Steurbout, dr. D Hamilton), Greenpeace (dr. M. Krauter), Industry (Bayer, BASF, Syngenta) • To convey relevant issues from a stakeholders perspective • To bring in relevant expertise (e.g. from USA) • Emerging issues in pesticide risk assessment • Implementation of project outcomes at EU level Jacob van Klaveren ACROPOLIS kick-off meeting

  16. Deliverables and milestones A deliverable is a result that has to be produced (e.g. a paper, a model, or any other result) A milestone is something that you have to achieve before you can continue All have to be done in time and as promised Jacob van Klaveren ACROPOLIS kick-off meeting

  17. Project Management Team • A representative of each beneficiary • Stop-go decisions • Contingency plan (coordinator) • Financial issues as far as they deviate from proposal • Gender issues Jacob van Klaveren ACROPOLIS kick-off meeting

  18. Thanks for your attention! jacob.van.klaveren@rivm.nl MCRA model : https://mcra.rikilt.wur.nl/ EFSA opinion : EFSA website  RIKILT report

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