SENSORY SYSTEM RECEPTORS & SENSORY PATHWAYS

1. LECTURE 3DR. ZAHOOR ALI SHAIKH SENSORY SYSTEMRECEPTORS & SENSORY PATHWAYS

2. Sensory system or Input system • What type of sensation do you know? • Touch • Fine • Crude • Pressure • Position • Vibration • Two point discrimination • Pain • Temperature • Cold • Warm • Stereognosis

3. How we feel the sensation? • Sensory receptor • Sensory pathway • Sensory cortex

4. Cont….COMPONENTS • Receptors • Peripheral nerves • Spinal cord • Tracts • Brain stem • Thalamus • Thalamocortical projection • Somatosensory cortex

5. Sensory Receptors • These are transducers that convert various forms of energy into action potentials . • The particular form of energy to which a receptor is most sensitive is called as its adequate stimulus.

6. Adequate stimulus Each type of receptor is most sensitive to a specific form of energy, called adequate stimulus, the receptor is almost non-responsive to the normal intensities of other forms of energy. e.g. rods & cones are stimulated by light not heat. Touch receptors are stimulated by touch.

7. Sensory receptors • Sensory receptors can be subdivided into: 1) Mechanoreceptors. 2) Thermoreceptors. 3) Nociceptors. 4) Proprieceptors. 5) Visceral receptors 6) Special senses.

8. Pressure

9. Tactile Receptors in the Skin

10. Skin Receptors

12. Receptor Properties 1.Receptor potential or Generator Potential • When we apply pressure, we generate depolarization in the receptor it is called Generator potential or Receptor potential. • Non propagated depolarizing potential.

13. What is the difference between generator potential and action potential? • Receptor potential • In the Receptor • Graded • Doesn’t obey all or none rule • Can be summated • Unpropagated • Action potential • In the Sensory Nerve fiber • Not Graded • Obeys all or none rule • Not summated • Propagated

14. RECEPTOR POTENTIAL & ACTION POTENTIAL

15. Note: if stimulus to the receptor is sub threshold then no action potential is generated in sensory nerve fiber Relation between receptor potential and action potential of sensory nerve

16. Sensory Transduction

17. 2.Adaptation or Desensitization • When stimulus of constant strength is applied to a receptor, some receptors can diminish the extent of their depolarization inspite of sustained stimulus. This is called adaptation. Degree of adaptation varies in different receptors.

18. Classification of receptors • Rapidly adapting or phasic receptors e.g. pacinian corpuscles, Meissners corpusle. Because of that we are not aware of sitting on the chair, wearing watch, wearing clothes. • Slowly or non adapting or tonic receptors e.g. Nociceptors, muscle spindles.

19. ADAPTATION OF RECEPTOR Tonic Phasic

20. RESPONSE OF PHASIC & TONIC MECHANORECEPTOR

21. 3.Coding of sensory information Why we feel touch, pain, warm sensation when all sensory nerve carry the information to brain as action potential?

22. Coding of sensory information • Due to the Doctrine of specific nerve energies. We have; • Specific receptors. • Specific sensory pathways. • Specific part of the brain they activate.

23. Law of projection • If we stimulate sensory pathway along its course to the sensory cortex, the conscious sensation produced is refered to the location of receptors. This principle is called as Law of projection. • If we stimulate sensory cortex area which receives impulses from left hand, patient reports sensation in the left hand, not in the head.

24. Cont….. Q. In patients whose limb was amputed (cut off) they complained of pain in the absent limb (Phantom limb), Why? Due to law of projection, the ends of nerves cut at the time of amputation when stimulated, sensation evoked are projected to where the receptor used to be present,i.e. in the limb.

25. Receptor field • Receptor field of a sensory unit is the area from which a stimulus produces response in that unit. • Smaller the receptive field – More precise the information e.g. Finger tips • Larger the receptive field- less precise the information e.g. arms, legs.

26. Discriminative ability of regions with small versus large receptive field

27. Recruitment of sensory units • Weak stimulus activates receptors with lowest threshold. • Strong stimulus activates those receptors also which have high threshold .

28. SPATIAL SUMMATION

29. Physiological classification of nerve fibers that transmit different types of sensations

30. Physiological classification of nerve fibers that transmit different types of sensations Number Origin Fiber type Ia Ib II III IV Muscle spindle, annulo-spiral ending. Golgi tendon organ. Muscle spindle, flower-spray ending, touch, pressure Pain and cold receptors; some touch receptors Pain, temperature, and other receptors A A A A Dorsal root C

31. Sensory Pathways Somatosensory pathways are THREE Neuron system

32. How Sensation are carried? • From receptors impulses are carried by sensory nerves, the sensory nerve have cell bodies in dorsal root ganglia. • Primary afferent fibers which carry cutaneous sensations are • Large myelinated fiber Aα and Aβ – propriception, touch, pressure. • Small myelinated fiber Aδ – fast pain • Small unmyelinated C fibers – slow pain

33. Sensory fiber go to dorsal horn in the spinal cord. • Dorsal horn represent a gate in which impulses in the sensory nerve fiber are translated into impulses in ascending tracts. • Dorsal horns are divided into laminae I – VII. (I – superficial, VII – deepest).

35. Sensory pathways or tracts areThree Neuron system 1. Dorsal column or posterior column or Gracilis and cuneatus or leminscal system. • It carries sensations of fine touch, position, viberation, two point discrimination & stereognosis. 2. Anterolateral system • Ventral spinothalamic tract carries crude touch and pressure, • Lateral spinothalamic tract carries pain and temperature.

36. Spinal Tracts

38. Dorsal Column System Medulla

39. Anterolateral System

41. Dorsal Column Anterolateral System

44. DORSAL COLUMN PATHWAY • CARRIES FINE TOUCH, POSITION, PRESSURE, VIBRATION, TWO POINT DESRIMINATION stereognosis • AFFERENT SENSORY FIBERS Aβ TYPE. • VERY FAST VELOCITY 30 – 70 m/s • 3 NEURON SYSTEM (SEE THE DIAGRAM) ANTEROLATERAL PATHWAY • CARRIES PAIN & TEMPRATURE (lat. Sp.Th) • CRUDE TOUCH & PRESSURE (VENT, Sp. Th) • AFFERENT SENSORY FIBERS Aδ – 6 – 30 m/s (MYELINATED) FAST PAIN • C FIBERS – 0.5 – 2 m/s (UNMYELINATED) SLOW PAIN • 3 NEURON SYSTEM (SEE THE DIAGRAM)

45. Different SensationsTEMPERATURE • Skin has cold sensitive area & heat sensitive area. Receptors are free nerve endings. • Cold receptors are 4 – 10 times more than warm sensitive spots. • Cold receptor responds from 10 – 38 oC. • Warm receptor responds from 30– 45 oC. • Afferent from cold receptors – Aδ & C fibers. • Afferent from warm receptors – C fibers. • Temperature sensation is carried via lateral spinothalamic tract.

46. THERMORECPTOR

47. Different SensationsPAIN • Pain receptors or nociceptors – free nerve endings. • Pain sensation are carried by two types of nerve fibers. • Aδ (myelinated) -2 – 5 μm.in diameter, conduction velocity – 12 – 30 m/sec. • For fast pain (sharp localized) • C fibers (unmyelinated) 0.4 – 1.2μm. in diameter, conduction velocity – 0.5 – 2 m/sec. • For slow pain (dull, diffuse) • Both Aδ & C fibers terminate in dorsal horn. Pain is carried via lateral spinothalamic tract.

48. PERCEPTION • Perception is conscious interpretation of external world by Brain due to sensory impulses delivered to Brain from sensory receptors. We perceive sounds , colors, smell. • Why we do not perceive X-Ray, light waves,MRI. Because we do not have receptors to respond.

49. Thank you