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Membran e Receptor for Antigen

Membran e Receptor for Antigen

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Membran e Receptor for Antigen

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  1. MembraneReceptor for Antigen • Kelompok : 4 • NindaSahriyani (105090100111010) • GanysTri S. (115090107111020) • Agatha Mia (115090101111010) • Vita Agustina(115090100111011) • Jurusan Biologi • Fakultas Matematika dan Ilmu pengetahuan Alam • Universitas Brawijaya • 2013

  2. Three Limbs of immune respone Fig 1. Three Limbs Immune Respone

  3. Major Histocompatability Complex (MHC) • Group of genes that code for proteins that found on the surfaces of cells that help the immune system recognize foreign substances • Also known as HLA (Human Leukocyte Antigen) • Two types:

  4. Function of MHC • Determinate between the self and nonself antigens • Presenting antigen to T cells • Determinate interaction between B cells, T cells and other cells.

  5. Degradation Process (Processing and Presentation) Antigen There are 3 ways of processing and presentation antigens : • Protein from extracellular pathogen broken down and processed by exogen pathway • Protein from self-protein and virus protein processed by endogen pathway • Lipid and derivate processed like extracelular protein and endosom, with CD1, that similiar to MHC and presented to CD8 T cell. Function of MHC

  6. Fig 2. MHC Structures

  7. Table 1. Differences between Class I and Class II MHC

  8. Similarities of Antigen Presenting by MHC molecules • Presented to T cell on the surface of APC (Antigen Presenting Cell) • Every MHC can only bind to single antigen fragment at one time, at the peptide binding cleft • The presented antigen fragment is only amino acid chain • The binding is done intracellular

  9. Fig 2. Class I MHC Antigen Presenting Pathway

  10. Fig 3. Class II MHC Antigen Presenting Pathway

  11. T Cell Receptor (TCR) T • Mature T cell have thousands identical receptor on the cell surface • 2 kinds of receptor: • Alpha/beta (αβ) chain T cell (95%) • Gamma/delta (γδ) chain T cell (5%) • Co-receptor : CD4 and CD8

  12. T Cell Receptor Complex: TCR-CD3 Fig 5. TCR-CD3 TCR binding to MHC-antigen The long cytoplasmic tail of the CD3 functions in signal transduction.

  13. Role of co-receptors in TCR binding affinity Fig. 6 Role of co- receptor CD 4 and CD8 : they may act as adhesion molecule helping the T cell bind to the APC during antigen presentation for duration that is sufficient for antigen recognition or act as signal transducers.

  14. THANK YOU FOR YOUR ATTENTION… ANY QUESTION???

  15. VIDEO Link : T Cell Dependent Antigens http://highered.mcgraw-hill.com/olc/dl/120 110/micro33.swf Cytotoxic T Cell http://highered.mcgraw-hill.com/olc/dl/120110/micro34.swf