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Fascioliasis

Fascioliasis

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Fascioliasis

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  1. Fascioliasis Rebecca Flint

  2. Fascioliasis has world wide effects • WHO designated extremely neglected disease • Cases in 51 different countries • 17 million people affected

  3. Oral-fecal transmission route • Reservoir in livestock • Watercress

  4. Disease manifests in the liver • Chronic phase • Producing eggs in bile ducts • Asymptomatic • Symptomatic • Acute phase • Flukes traveling to bile ducts • Nausea, vomiting, abdominal pain • Inflammation and bleeding • Liver tissue destruction

  5. Diagnosis can be difficult • Stool ova test • ELISA or Western Blot • Liver ultrasound

  6. Few drugs have been used for treatment • Bithionol • - Less effective • Triclabendazole • - 1983 • - Effective against early stage parasites • - Inhibits parasitic microtubule formation • - Resistance in 1995

  7. Cathepsin L proteases vaccine testing • Fascilitate in tissue penetration, feeding, and immune system evasion • Cathepsin L1 and L2 are the major fasciola proteases

  8. FhSAP2 as a potential vaccine • Potential to protect against subsequent fasciola hepatica metacercariae infections • Fluke burden • Reduced 83.3% with cDNA-FhSAP2 • Reduced 60% with FhSAP2 protein

  9. Difficulty controlling Fasciola spread • Individualized control plans • Separation of livestock and farming • Sanitation • Cooked vegetables

  10. References • http://www.stanford.edu/class/humbio103/ParaSites2006/Fascioliasis/index.htm • http://perutravelnews.info/Peru_geography.html • http://www.dpd.cdc.gov/dpdx/html/fascioliasis.htm • http://www.bvgh.org/Biopharmaceutical-Solutions/Global-Health-Primer/Diseases/cid/ViewDetails/ItemID/23.aspx • Farid Z, Kamal M, Woody J (1988). Treatment of acute toxemic fascioliasis. Trans R Soc Trop Med Hyg, 82, 299. • Dawes B. Some apparent effects of Bithionol (Actamer) on Fasciola hepatica. Nature. 209. 424–425. • http://www.cdc.gov/parasites/fasciola.html • http://www.sciencedirect.com/science/article/pii/S0020751903001711 • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260556/ • http://www.who.int/foodsafety/foodborne_disease/Fascioliasis.pdf • http://www.who.int/bulletin/archives/77(4)340.pdf • Neglected tropical diseases of the Middle East and North Africa: Review of their prevalence, distribution and opportunities for control • http://ac.els-cdn.com/S001448000700010X/1-s2.0-S001448000700010X-main.pdf?_tid=82eb0beb26d3784c63b3fcd658db039e&acdnat=1333563684_9e8fd6d27e3ffb1fd0161e28213982e4 • http://ac.els-cdn.com/S0020751903001711/1-s2.0-S0020751903001711-main.pdf?_tid=34f4d59141feb9d940a11d5c27187d3b&acdnat=1333563744_ba4fe537c7008eb34a64f709d662597b • http://ac.els-cdn.com/S0304401709001642/1-s2.0-S0304401709001642-main.pdf?_tid=2428d0ca1d59c164e22da2549d1bead9&acdnat=1333563799_59532b3db68dd198cec5000e8417e16d • http://ac.els-cdn.com/S1090023399903775/1-s2.0-S1090023399903775-main.pdf?_tid=241c67a32596ceb3ca75909744fc71c6&acdnat=1333563903_2ff3d34d9679ff21d2ec7451b180156a • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260556/