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Cryoprecipitate: Cold Plasma Source for Bleeding Disorders

Cryoprecipitate is a cold precipitate of plasma enriched with Fibrinogen, VIII, vWF, thrombospondin, and more, vital for clotting disorders. Ensure proper administration to avoid waste and maximize efficacy.

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Cryoprecipitate: Cold Plasma Source for Bleeding Disorders

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  1. Cryoprecipitate Laura Cooling MD, MS Associate Medical Director Transfusion Medicine

  2. Cryoprecipitate • Prepared from FFP that is allowed to thaw overnight at 4C. It is literally the “cold” precipitate” of plasma • Enriched source of Fibrinogen, VIII, vWF • Contains thrombospondin, fibronectin, some IgM antibodies

  3. Cryoprecipitate Each unit • 7-15 cc total volume • 250 mg fibrinogen • 80-120 U VIII Adult: Pool several units (avg 10) for adults

  4. Indications for Cryoprecipitate • Hypofibrinogenemia (<100 mg/dL) and bleeding/prior to surgery • Dysfibrinogenemia and bleeding/prior to surgery • Factor XIII deficiency • Fibrin patch-Oto, cardiothoracic, dental • Uremic bleeding Less Common Now (better alternatives) • von Willebrand Disease, VIII deficiency

  5. Common Mistakes Inadequate dose • order 1 unit (10 cc) for adult Inappropriate Administration • Patient with volume overload and Multifactor deficiency (long PT/PTT) Over-ordering/ Over transfusion • Surgery responsible for 65% cryo waste

  6. Cryoprecipitate Administration • ABO compatible preferred but not required • Infused within 4 hrs of thaw, pooling Dose:10 pooled (adult) 1 unit/5 kg (infants/children) Rate: Like FFP (200-250 cc/20-30 min) Efficacy:Increase fibrinogen 5 mg/dl /unit 10 units=raise fibrinogen 50 mg/dl

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