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Scanner Validation for Clinical Trials Network: Ensuring Reliable PET Data Quality

The Scanner Validation via the SNM Clinical Trials Network Phantom Program at Huntsman Cancer Institute, University of Utah, aims to validate scanner performance for multi-center clinical trials. With a focus on PET lesion detectability, imaging protocols, and SUV measurements, the goal is to generate a validation tool for reliable PET data. The program utilizes various phantoms, imaging processes, and evaluation criteria to assess scanner quantitative validation and overall performance. Join the initiative to enhance scanner reliability in clinical trials.

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Scanner Validation for Clinical Trials Network: Ensuring Reliable PET Data Quality

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  1. Scanner Validation via the SNM Clinical Trials Network Phantom ProgramPaul E. ChristianMolecular Imaging ProgramHuntsman Cancer InstituteUniversity of Utah

  2. Scanner Validation Sub-Committee Purpose:Ensure scanner meets certain performance criterion needed for multi-center clinical trials via a clinical simulation phantom exercise.

  3. Validate scanner performance • PET lesion detectability not consistent across vendors. • Imaging/processing protocols not consistent between sites. • SUV measurements not consistent across vendors nor sites. • PET data submitted to FDA for multi-center drug studies not deemed reliable. • Goal: Generate measurement tool to validate reliable multi-center PET data

  4. Quality Control • Dose Calibrator • CT Scanner • CT checks • Calibration • Inspection • PET Scanner • Blank scan • Constancy • PET and CT alignment • Record of PMs and calibrations

  5. Scanner Constancy Courtesy: Paul E. Christian

  6. Commonly Used PET Phantoms Commercial phantoms IEC NEMA NU-2 ACRIN ACR AAPM QIBA CROs

  7. NEMA-IEC NU-2 Phantom 68Ge resin filled phantom 270.8 day T1/2 4.6 mCi Bkgd 0.44 mCi/ml Spheres 1.75 mCi/ml 4:1 sphere/background ratio Atten Coeff 0.103 mm2/g at 511keV 59+-7 HU

  8. Ten Sites, Three vendors(GE 4-PET/CT, 2-PET; Philips 1-PET/CT; Siemens 3-PET/CT) Kinahan, Doot, U Wash.

  9. CTN Oncology Chest Phantom • Clinical simulator to measure: • Lesion detectability • Lesion quantitation • Image noise / texture

  10. CTN Oncology Chest Phantom • Fill with F-18 FDG • Precision Filling Technique • Clinical Concentration • Fixed Lesion/Background Ratio

  11. Precision 18F Fillable Phantom Repeat studies using a precision filling technique with F-18 Paul E. Christian, Keith Bigham, unpublished data 2008

  12. Fill phantom (precise technique) • Performing imaging according • to prescribed protocol • Image after specific time delay • Reconstruction parameters • MD to identify lesions • Submit images for review • Quantitative measurements (SUVmax and SUVave) • At site • At core lab Imaging Process

  13. Clinical Simulation PhantomsEvaluate: Image performance -Accuracy of dose -Acquisition -Reconstruction/filter -Interpretation # Lesions detected Location of detected lesions SUV measurements (site) -Verify SUVs at core lab -Evaluate DICOM images (core lab) Image quality of PET/CT scanner -Uniformity -Resolution -Contrast -Noise -PET/CT alignment -Lesion detectability -Attenuation correction -Quantitative accuracy Evaluation Criterion:

  14. Scanner Quantitative Validation Assessment: SUV background accuracy Lesion SUV accuracy DICOM transfer valid Validation of SUV DICOM

  15. 17 scanners validated to date • 13 sites • 11 more sites have phantoms • 20+ additional sites scheduled (worldwide expansion) Scanner Validation Progress

  16. DICOM image compatibility • Ability to provide quantitative images • Ability to provide accurate SUVs • Scanner operation/calibration • Dose calibrator Scanner Validation Site Problems

  17. Scanner Validation Sub-Committee 2010 Goals: Testing brain imaging phantom

  18. 2010 Goals: Testing myocardial perfusion imaging phantom (3 clinical scenarios) Scanner Validation Sub-Committee

  19. Scanner Validation Sub-Committee Accomplishments: • Development of scanner validation process • Implement review and quality assurance testing • Provide on-line phantom instructional video • Administration of oncology demonstration project • Oncology phantom imaging at 40+ sites • Development of myocardial perfusion phantom • Development of brain phantom

  20. 2010 Goals: Streamline phantom qualification program Develop central archive for images Develop process for long term maintenance and administration of phantom site qualification Implement multi-site testing of brain and cardiac phantoms Scanner Validation Sub-Committee

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