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CD45

64y F patient WBC = 101 Thrombocytopenia Anemia PB morphology 90% blasts. SSC. CD45. CD45. BM analysis CD10/CD34/CD45/CD19 80% disease CD45 dim, CD34+ CD19-, CD20-. SSC. CD34. CD19. BM analysis CD7/CD34/CD45/CD3 CD3-, CD7-. SSC. CD3. CD7. BM analysis CD13/CD34/CD45/CD33

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CD45

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  1. 64y F patient WBC = 101 Thrombocytopenia Anemia PB morphology 90% blasts SSC CD45 CD45 BM analysis CD10/CD34/CD45/CD19 80% disease CD45 dim, CD34+ CD19-, CD20- SSC CD34 CD19

  2. BM analysis CD7/CD34/CD45/CD3 CD3-, CD7- SSC CD3 CD7 BM analysis CD13/CD34/CD45/CD33 CD33+dim, CD13+ CD13 CD33 CD34

  3. BM analysis CD13/CD33/CD45/CD14 CD14- SSC CD45 CD14 BM analysis CD15/CD117/CD45/CD4 CD15-, CD4-, CD117+ SSC CD15 CD117

  4. FACS - indications for therapy Antibodies as therapeutics CD20 (Rituximab) CD33 (Myelotarg) CD52 (MabCampath) Membrane receptors as a target CD117 - Gleevec target (AML, MM)

  5. And more...

  6. Beads based assays cytokines Growth factors Signaling molecules

  7. 2 1 4 3 5 3 / 1 6 X 7 8 recip 9-22 13 Y 18 9-12 14 15 16 20 21 17 19 22 Ph Chromomycin A 3 GC Chromosomes…in FACS Hoechst 33258 AT

  8. Signal transduction Phospho-specific antibodies Activated signaling molecule Signaling molecule P ERK, JNK, p38 PI3K cell cycle associated kinases Activated cells; malignant cells

  9. The future….(already here) Organelles (mitochondria, golgi, cytoskeleton) Ions pH Membrane potential

  10. Flow cytometry From cellular identity to cellular physiology תודה, ואחרצהרייםטובים...

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