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Current Perspectives on the Management of Iron Deficiency in Chronic Heart Failure

Current Perspectives on the Management of Iron Deficiency in Chronic Heart Failure. Background. Program Overview. The Impact of Iron Deficiency in Chronic Heart Failure. ID vs Anemia in CHF. Prevalence of ID in Patients With CHF.

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Current Perspectives on the Management of Iron Deficiency in Chronic Heart Failure

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  1. Current Perspectives on the Management of Iron Deficiency in Chronic Heart Failure

  2. Background

  3. Program Overview

  4. The Impact of Iron Deficiency in Chronic Heart Failure

  5. ID vs Anemia in CHF

  6. Prevalence of ID in Patients With CHF

  7. ID Is Common Irrespective of Ethnicity, Sex, or Anemia Status

  8. Causes of ID in CHF -- Absolute and Functional

  9. Common Iron Deficit in Patients With CHF

  10. Impact of ID in Patients With CHF

  11. Impact of ID in Patients With CHF (cont)

  12. ID Impairs Mitochondrial Function

  13. Summary

  14. Treating Iron Deficiency in Chronic Heart Failure

  15. Correction of ID as a Therapeutic Target in HF

  16. FAIR-HF: Study Design

  17. FAIR-HF: Co-Primary Endpoints

  18. FAIR-HF: 6MWT Secondary Endpoint

  19. CONFIRM-HF: Study Design

  20. CONFIRM-HF: Primary Endpoint

  21. EFFECT-HF: Study Design

  22. EFFECT-HF: Primary Endpoint Change in Peak VO2

  23. Meta-Analysis: Time to First Event Outcomes

  24. Oral Iron Replacement Does Not Work in HF

  25. ESC Guidelines for the Diagnosis and Treatment of HF

  26. Recent and Ongoing Trials in Iron Replacement Therapy

  27. 4 Ongoing Large RCTs in Patients With HF

  28. AFFIRM-AHF

  29. FAIR-HF2

  30. HEART-FID

  31. IRONMAN

  32. Potential Mechanism of Action of IV Iron

  33. Effect of ID and Iron Supplementation on Cardiomyoctye Function

  34. Summary

  35. Iron Deficiency in Chronic Heart Failure Across the Spectrum of Ejection Fraction

  36. Classification of HF According to EF

  37. Prevalence of ID Across EF Spectrum of HF

  38. ESC Recommendations Largely For HFrEF

  39. Most Trial Data Based on Patients With HFrEF

  40. Ongoing Trials With IV FCM in HF

  41. Conclusion

  42. Does Ejection Fraction Matter?

  43. Diagnosing Patients With HFpEF

  44. Managing Patients With HFpEF

  45. Effect of ID on Patients With HFpEF

  46. The Need for Trials on Patients With HFpEF and ID

  47. FAIR-HFpEF Trial

  48. FAIR-HFpEF Trial (cont)

  49. Summary

  50. Abbreviations

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