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LIPOSOMES

LIPOSOMES. The lamellar phases of phospholipids wherein stacked phospholipid bilayers are separated by layers of the aqueous phase convert spontaneously into multilamellar liposomes at increased water content.

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LIPOSOMES

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  1. LIPOSOMES The lamellar phases of phospholipids wherein stacked phospholipid bilayers are separated by layers of the aqueous phase convert spontaneously into multilamellar liposomes at increased water content. Unilamellar phospholipid liposomes are hollow spherical particles consisting of single phospholipid bilayer shell with the aqueous phase inside and outside of this shell.

  2. Neutron scattering and LLB: http://www-llb.cea.fr/index_e.html

  3. SANS Polydispersity

  4. Evaluation Guinier approximation: Fit:

  5. Models: Single-shell Multi-shell Multi-shell + Linear profile of headgroup Multi-shell + Triangular profile of headgroup

  6. Contrast Variation and Guinier approximation

  7. Contrast Variation and Fitting

  8. Effect of additional amphiphilic molecules

  9. YUMO

  10. PAXE

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