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KEY CONCEPT Mutations are changes in DNA that may or may not affect phenotype.

KEY CONCEPT Mutations are changes in DNA that may or may not affect phenotype. Some mutations affect a single gene, while others affect an entire chromosome. Many kinds of mutations can occur, especially during replication. A mutation is a change in an organism ’ s DNA. mutated base.

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KEY CONCEPT Mutations are changes in DNA that may or may not affect phenotype.

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  1. KEY CONCEPT Mutations are changes in DNA that may or may not affect phenotype.

  2. Some mutations affect a single gene, while others affect an entire chromosome. • Many kinds of mutations can occur, especially during replication. • A mutation is a change in an organism’s DNA.

  3. mutated base Gene mutation: mutations that affect a single genes 1st bullet • Point mutation-substitutes one nucleotide for another

  4. More about gene mutations… 2nd bullet • Frameshift mutation- inserts or deletes a nucleotide in the DNA sequence.

  5. Chromosomal Mutations: mutations that affect an entire chromosomes • Chromosomal mutations may occur during crossing over 1st bullet • Chromosomal mutations affect many genes. • Gene duplication results from unequal crossing over.

  6. More about chromosomal mutations… • Translocation results from the exchange of DNA segments between nonhomologous chromosomes. 2nd bullet

  7. blockage no blockage Potential impact: Chromosomal mutations typically have a large effect on an organism; may result in a disrupted gene or abnormal regulation of genes • Mutations may or may not affect phenotype • Point mutations may result in premature stop codons or amino acids with very different properties from the correct amino acid… • May disrupt a splice site • May disrupt a regulatory DNA sequence • Frame mutations may result in a completely altered protein or a premature stop codon

  8. Silent: some mutations have no apparent effect • A point mutation may not change the amino acid that is coded for • Even if a change occurs, the change may be in an intron that is removed & this has no effect • A change may not significantly affect the function of a protein if the new amino acid is similar to the correct one or occurs away from the active site or does not influence protein structure

  9. Mutagens: agents in the environment that can change DNA • Replication errors can cause mutations. • Mutagens, such as UV ray and chemicals, can cause mutations. • Some cancer drugs use mutagenic properties to kill cancer cells.

  10. Summary Stuff: • Mutations in body cells do not affect offspring. • Mutations in sex cells can be harmful or beneficial to offspring. • Natural selection often removes mutant alleles from a population when they are less adaptive.

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