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Fibroblast growth factor 23, bone mineral density and risk of hip fracture among older adults

Fibroblast growth factor 23, bone mineral density and risk of hip fracture among older adults. Osteoscoop - Issue N°319 – January 2014. Kidneys. Phosphaturia Inhibition 1,25(OH) 2 D synthesis. Parathyroid gland. OB. FGF23. OCy. Lower PTH secretion. FGF23. Lower BMD?

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Fibroblast growth factor 23, bone mineral density and risk of hip fracture among older adults

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  1. Fibroblast growth factor 23,bone mineral density and risk of hip fracture among older adults Osteoscoop - Issue N°319 – January 2014

  2. Kidneys Phosphaturia Inhibition 1,25(OH)2D synthesis Parathyroid gland OB FGF23 OCy Lower PTH secretion FGF23 Lower BMD? Increased fracture risk?

  3. Kidneys Phosphaturia Inhibition 1,25(OH)2D synthesis Parathyroid gland OB OB FGF23 OCy OCy Lower PTH secretion FGF23 FGF23 Lower BMD? Increased fracture risk? 2008 Women 1329 Men Age > 64 Average follow-up: Average 8.2 years Increased hip & lumber spine BMD Association High serum FGF23 FGF23

  4. Kidneys Phosphaturia Inhibition 1,25(OH)2D synthesis Parathyroid gland OB OB FGF23 OCy OCy Lower PTH secretion FGF23 FGF23 Lower BMD? Increased fracture risk? 2008 Women 1329 Men Age > 64 Average follow-up: Average 8.2 years Increased hip & lumber spine BMD Association High serum FGF23 FGF23 Increased hip fracture risk No association

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