Infectious Diseases • Unit 4 Lesson 5 plan
Do now • Brainstorm: • The 1918 flu appeared suddenly and killed millions of people. Where does a virus like this come from?
Antigenic drift and Antigenic shift Only some viruses can do this because It requires a segmented genome!
Non-Segmented Genomes Virus B Virus A Host cell
Segmented Genomes Virus B Virus A Host cell
H = hemagglutinin (surface protein used to attach and enter host cell) N = neuraminidase (surface protein used to exit host cell) Examples: H1N1: infects cells of upper respiratory tract; less virulent but easily spread H5N1: infects cells of lower respiratory tract; more virulent but not easily spread
Wrap up • Complete your worksheet and hand it in.