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DIAN Informatics & Data Management

DIAN Informatics & Data Management. Dan Marcus July 25, 2008. Anatomy of a DIAN visit. Performance Sites. Performance Sites. Performance Sites. Performance Sites. Performance Sites. Performance Sites. Study coordinators. Study coordinators. Performance Sites. Clinical,

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DIAN Informatics & Data Management

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  1. DIAN Informatics & Data Management Dan Marcus July 25, 2008

  2. Anatomy of a DIAN visit

  3. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) PET QC (U Mich.) Biomarkers Core Biostats support Investigators

  4. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) Biomarkers Core PET QC (U Mich.) Biostats support Investigators

  5. Performance Sites Performance Sites Biomarker samples Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Clinical Participant demographics Neurological exam Physical exam Psychometrics UDS Web-based tests Biomarkers Plasma, blood, & CSF volumes FedEx tracking #’s CSF lab result (blood cell counts, protein & glucose ) Clinical, Psychometrics, Biomarker info Genetics Core DIAN CCC (ADCS) Biomarkers Core Derived measures Mutation status Aβ levels

  6. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) Biomarkers Core PET QC (U Mich.) Biostats support Investigators

  7. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) Biomarkers Core PET QC (U Mich.) Biostats support Investigators

  8. DIAN Central Archive (Wash U.) DIAN CCC (ADCS) Push “real-time” data Pull nightly updates Quality control

  9. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) Biomarkers Core PET QC (U Mich.) Biostats support Investigators

  10. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) PET QC (U Mich.) Biomarkers Core Biostats support Investigators

  11. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Performance Sites • Web-based upload • Automatic deidentification of image files • Sites will be contacted directly by Mayo and Michigan to resolve acquisition issues MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) PET QC (U Mich.) Standard analysis pipeline

  12. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) PET QC (U Mich.) Biomarkers Core Biostats support Investigators

  13. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) PET QC (U Mich.) Biomarkers Core Biostats support Investigators

  14. DIAN Central Archive (https://cnda.wustl.edu) • All DIAN data (acquired and derived) will be accessible through the central archive. • Data will reside in site specific projects with project-based user access privileges. • Data will be shared intoDIAN-wide & public accessprojects according to DIANdata sharing policies. DIAN Central Archive (Wash U.) Biostats support Investigators

  15. Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Performance Sites Study coordinators Study coordinators Performance Sites Clinical, Psychometrics, Biomarker info Genetics Core MRI, PET MRI QC (Mayo) DIAN Central Archive (Wash U.) DIAN CCC (ADCS) PET QC (U Mich.) Biomarkers Core Biostats support Investigators

  16. Informatics Core Personnel • Dan Marcus (core leader) • Angela Jones (data coordinator) • Tim Olsen, Mohana Ramaratnam, Kevin Archie (programmers) • Close coordination with the ADCS

  17. http://www.dian-info.org

  18. http://nrg.wikispaces.com/DIAN

  19. Mailing lists • Hosted by the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) • Initial lists:dian-network@www.nitrc.orgdian-imaging@www.nitrc.orgdian-data@www.nitrc.org • To subscribe/unsubscribe:http://www.nitrc.org/mailman/listinfo/{listname}(e.g. http://www.nitrc.org/mailmain/listinfo/dian-network)

  20. Help and Support • Quasi-24/7 support (Sorry Australia) • Phone support: (314) 315-4937 • Rings to my cell and on-call technical staff • Email support: help@dian-info.org • Delivered to all informatics core staff

  21. Ongoing efforts • Data management tool development • Data exchange methods between central database and supporting sites (ADCS, Mayo, Michigan) • Coordination with cores • Coordination with AlzForum • Training materials

  22. Breakout plans • 1:00 – 2:00 Data management breakout • 1:00 – 2:00 Imaging breakout (the boring stuff) • 2:00 – 3:00 Joint data/imaging breakout (the exciting stuff)

  23. DIAN Biostatistics ChengjieXiong July 25, 2008

  24. DIAN Biostatistics Core Oversee the statistical quality control of data & prepare final datasets for distribution/analysis; Lead/collaborate/consult on the statistical design/analyses & in report preparation; Implement/develop appropriate longitudinal statistical models for DIAN markers; Serve as an advisory group for outside researchers interested in DIAN data.

  25. Biostatistics Core Personnel Core leader: Dr. Chengjie (Ken G) Xiong, Database manager: Dr. Elizabeth Grant (Mr. Scot Fague). Interactions: Informatics Core/ADCS, and other Cores of DIAN.

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