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Ethics and Organ Transplantation

Ethics and Organ Transplantation. Divya Bappanad March 23, 2010. History of Organ Transplant. 1954 living relating kidney transplant( Dr. Joseph Murray and Dr. David Hume Boston) 1962 cadaveric kidney transplant by (Dr. Joseph Murray and Dr. David Hume Boston)

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Ethics and Organ Transplantation

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  1. Ethics and Organ Transplantation DivyaBappanad March 23, 2010

  2. History of Organ Transplant • 1954 living relating kidney transplant( Dr. Joseph Murray and Dr. David Hume Boston) • 1962 cadaveric kidney transplant by (Dr. Joseph Murray and Dr. David Hume Boston) • 1963 lung transplant (Dr. James Hardy Mississippi) • 1967 liver transplant( Dr. Thomas Starzl Colorado) and heart transplant(Dr. Christiaan Barnard South Africa) • 1981 heart/lung transplant(Dr. Norman Shumway California) • 1983 FDA approves cyclosporin

  3. Guiding Principles in Medical Ethics • Autonomy • The right of individuals to self-determination • Beneficence • Physicians should act in the best interest of their patients • Non-maleficence • Physicians should not cause harm to their patients • Justice • Fairness and equality

  4. Increasing Organ Donation • Limited Resource • Cadaveric Organs • Mandated Choice • Presumed Consent • Incentives • Prisoners

  5. Consent • Presumed consent • Explicit Consent • Informed consent

  6. Informed Consent • Diagnosis • Nature and purpose of treatment • Risks and benefits of treatment • Alternatives • Risks and benefits • Risks and benefits of not having treatment

  7. Increasing Organ Donation • Living Donors • Buying and selling of organs • Unfair pressure on economically disadvantaged • Wealthy people have unfair access • Donor and recipient safety

  8. Organ allocation • Limited resource • Distributive justice • How to fairly divide resources • Equal access • Maximum benefit

  9. Distributive Justice • Equal Access • Everyone should be able to access it equally • Length of Time • Age of recipient • Reasons for equal access: exclude individual worth from equation • Exclude Medical “worthiness” i.e. smoking or ETOH use • Exclude Social “worthiness” i.e. prisoners

  10. Distributive Justice • Maximum benefit • Maximize the number of successful transplants • Medical need • Probability of success • Reasons for maximum benefit: limited resource and should avoid waste • Second transplant • Factor in medical outcome

  11. Current Organ Distribution System • Medical need • Probability of Success • Time on Waiting List

  12. WHO Guiding Principle 1 • Autonomy • Cells, tissues and organs may be removed from the bodies of deceased persons for the purpose of transplantation if: • (a) any consent required by law is obtained, and • (b) there is no reason to believe that the deceased person objected to such removal.

  13. WHO Guiding Principle 2 • Beneficence • Physicians determining that a potential donor has died should not be directly involved in cell, tissue or organ removal from the donor or subsequent transplantation procedures; nor should they be responsible for the care of any intended recipient of such cells, tissues and organs.

  14. WHO Guiding Principle 3 • Autonomy, Non-maleficence, Justice • In general living donors should be genetically, legally or emotionally related to their recipients. • Informed, voluntary consent • Professional follow up ensured and organized • Selection criteria • Non coercive

  15. WHO Guiding Principle 4 • Non-maleficence • Minors and legally incompetent people • No cells, tissues or organs should be removed from the body of a living minor for the purpose of transplantation other than narrow exceptions allowed under national law. • Specific measures should be in place to protect the minor and, wherever possible the minor’s assent should be obtained before donation.

  16. WHO Guiding Principle 5, 6, and 8 • Beneficence • Cells, tissues and organs should only be donated freely without any monetary payment or reward of monetary value. • The prohibition on sale or purchase of cells, tissues and organs does not preclude reimbursing reasonable and verifiable expenses incurred by the donor, including loss of income, or paying the costs of recovering, processing, preserving and supplying human cells, tissues or organs for transplantation.

  17. WHO Guiding Principle 7 • Non-maleficence • Physicians and other health professionals should not engage in transplantation procedures, and health insurers and other payers should not cover such procedures, if the cells, tissues or organs concerned have been obtained through exploitation or coercion of, or payment to, the donor or the next of kin of a deceased donor.

  18. WHO Guiding Principle 9 • Justice • The allocation of organs, cells and tissues should be guided by clinical criteria and ethical norms, not financial or other considerations. • Allocation rules, defined by appropriately constituted committees, should be equitable, externally justified, and transparent.

  19. Citations • Informed Consent. American Medical Association< http://www.ama-assn.org/ama/pub/physician-resources/legal-topics/patient-physician-relationship-topics/informed-consent.shtml> • WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation< http://www.searo.who.int/LinkFiles/BCT_WHO_guiding_principles_organ_transplantation.pdf> 26 May 2008.

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