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Impact of NaB, SAHA, and TSA on Cell Viability of IMR32 and SH-EP Cell Lines

This study investigates the effects of sodium butyrate (NaB), suberoylanilide hydroxamic acid (SAHA), and trichostatin A (TSA) on the viability of IMR32 and SH-EP cancer cell lines. We measured cell viability percentages at various concentrations (0-20 mM for NaB, 0-5 mM for SAHA, and 0-5 mM for TSA). Our findings highlight the differential sensitivity of these cell lines to histone deacetylase inhibitors, providing insights into potential therapeutic strategies for neuroblastoma and related cancers.

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Impact of NaB, SAHA, and TSA on Cell Viability of IMR32 and SH-EP Cell Lines

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  1. A S-type: SH-EP (n.a.) CA2E (a.) SK-N-AS (n.a.) N-type: IGRN-91 (a.) IGRN-B8 (a.) LAN-1 (a.) IMR32 (a.) SH-SY-5Y (n.a.) 120 100 80 viability % 60 40 20 0 0 5 10 15 20 mM NaB 120 100 IMR32 SH-EP - - + 80 zVAD viability % 60 no 40 20 0 0 5 10 15 20 NaB mM SAHA 120 100 SAHA 80 viability % 60 40 TSA 20 0 0 1 2 3 4 5 mM TSA B

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