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S. Vangaveti and A. T .

Coarse grained models for signaling phospholipids Alex Travesset, Iowa State University, DMR 0748475. Membranes are walls that separate the interior and the exterior of living cells. They are made mainly of phospholipid molecules (PLs). TWO OF THE MOST RELEVANT SIGNALING PHOSPHOLIPIDS. PIP 2.

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S. Vangaveti and A. T .

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  1. Coarse grained models for signaling phospholipidsAlex Travesset, Iowa State University, DMR 0748475 Membranes are walls that separate the interior and the exterior of living cells. They are made mainly of phospholipid molecules (PLs). TWO OF THE MOST RELEVANT SIGNALING PHOSPHOLIPIDS PIP2 PLs do more than separate inside from outside: PLs like PIP2 and PA (fig. right) are present in less than 1% in membranes, yet participate in almost all signaling processes. PA Phosphoryl groups Understanding how signaling PLs interact with other PLs and proteins is key. A crucial role is played by phosphoryl groups. COARSE-GRAINING CHARGES Atomic level descriptions are too demanding, so in order to reach the relevant time scales, we developed a coarse-grained model, incorporating both electrostatic as well as specific ionic effects and charge regulation by protonation. We have predicted zeta-potentials, ion accumulation, etc.. successfully comparing it with experiment. Current work is focused on the extension to protein-lipid interactions. Comparison model (solid line) with experiment (symbols) S. Vangaveti and A. T.

  2. Developing Teaching by Inquiry in IowaAlex Travesset, Iowa State University, DMR 0748475 The Iowa legislature introduced the Iowa core curriculum, which will be implemented by 2011, and includes teaching science by inquiry. With notable exceptions, teaching by inquiry presents a very important challenge, with few opportunities for teachers to get educated or retrained. As part of our broad impact efforts, we organized a teaching by inquiry workshop during Presidents day 2010, where 60 teachers from many different counties in Iowa participated. • The workshop included: • Hands on master class. • Round table with experts from Iowa state on teaching by Inquiry. • Resources both on and off line. The success prompted the organization of a more extensive workshop for summer 2011. A parallel workshop for high school students “first college experience for HS students”, was also organized, with the purpose to introduce the students to college physics. Over 40 students, which the teachers themselves brought to the campus, participated.

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