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The Role of Influenza Vaccination in Preventing Asthma Exacerbations in Pediatric Patients

This review explores the effectiveness of the influenza vaccine in pediatric patients with asthma, examining its role in preventing exacerbations as indicated by hospitalization, emergency room visits, and clinic visits. The analysis incorporates findings from various studies that utilized Medline searches with MeSH terms to provide evidence on whether the influenza vaccine decreases asthma-related complications and if it may inadvertently lead to exacerbations. The studies examined include randomized controlled trials and cohort analyses that contribute to understanding the vaccine's impact on asthma management.

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The Role of Influenza Vaccination in Preventing Asthma Exacerbations in Pediatric Patients

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  1. Question 1: Among pediatric patients with asthma, can influenza vaccine prevent exacerbation using hospitalization, ER and clinic visits as surrogate markers?

  2. Search strategy. Medline search using MeSH ("Asthma"[Mesh] AND "influenza Vaccines"[Mesh])" with limits set to children

  3. Christy C, Aligne CA, Auinger P, Pulcino T, Weitzman M.: Effectiveness of influenza vaccine for the prevention of asthma exacerbations Arch Dis Child. 2004 89(8):734-5

  4. GRADE EVIDENCE SUMMARY

  5. GRADE BALANCE SHEET

  6. Question 2: Among pediatric patients with asthma, can influenza vaccine prevent influenza-related asthma exacerbation?

  7. Search strategy. Medline search using MeSH ("Asthma"[Mesh] AND "influenza Vaccines"[Mesh])" with limits set to children

  8. Bueving HJ, Bernsen RM, de Jongste JC, van Suijlekom-Smit LW, Rimmelzwaan GF, Osterhaus AD, Rutten-van Mölken MP, Thomas S, van der Wouden JC. Influenza vaccination in children with asthma: randomized double-blind placebo-controlled trial. Am J Respir Crit Care Med. 2004;169(4):488-93.

  9. GRADE EVIDENCE SUMMARY

  10. GRADE BALANCE SHEET

  11. Question 3: Among pediatric patients with asthma, can influenza vaccine lead to exacerbation?

  12. Search strategy. Medline search using MeSH ("Asthma"[Mesh] AND "influenza Vaccines"[Mesh])" with limits set to children

  13. Kramarz P, DeStefano F, Gargiullo PM, Davis RL, Chen RT, Mullooly JP, Black SB, Shinefield HR, Bohlke K, Ward JI, Marcy MS. Does influenza vaccination exacerbate asthma? Analysis of a large cohort of children with asthma. Vaccine Safety Datalink Team.Arch Fam Med. 2000;9(7):617-23.

  14. GRADE EVIDENCE SUMMARY

  15. GRADE BALANCE SHEET

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