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Mark A Collins Ph.D Marketing Manager, Cellular Imaging & Analysis

MIAHA - Minimum Information for a High Content Assay - a proposal for a standard for high content analysis data interchange. Mark A Collins Ph.D Marketing Manager, Cellular Imaging & Analysis. Review. Standard for Images and Data An image standard alone is not enough

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Mark A Collins Ph.D Marketing Manager, Cellular Imaging & Analysis

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  1. MIAHA - Minimum Information for a High Content Assay - a proposal for a standard for high content analysis data interchange Mark A Collins Ph.D Marketing Manager, Cellular Imaging & Analysis

  2. Review • Standard for Images and Data • An image standard alone is not enough • To analyse an image between different packages need more than just it’s type and format • How acquired • Magnification • Filters etc • Need a standard for data interchange that uses appropriate meta data to describe HCS/HCA images and data • Self describing format of XML proposed • Embrace and extend two existing standards • OME – Open Microscopy Environment • http://www.openmicroscopy.org/ • MIACA – Minimum Information for ACellular Assay • http://miaca.sourceforge.net/

  3. Practical Implementation of a Standard • Not just talk • Draft specification for HCS/HCA Data Interchange completed • MIAHA • Minimum Information for AHigh Content Assay • Testing the standard • HCSGateway™ Cellomics open interface to third party readers • GE INCELL 1000/3000 • Evotec Opera • Implemented the standard as part of the HCSGateway product • Get third party data in to our informatics • Get third party data out

  4. Implementing a Standard – Generation 1 HCSGateway transform to MIAHA 3rd party Analysis software Instrument data & Images MIAHA XML Document & image links Webservices Webservices API natively “reads” and writes MIAHA XML standard Cellomics Store database

  5. Implementing a standard - Generation 2 Instrument/Analysis software directly writes/reads MIAHA XML data MIAHA XML Document & image links Webservices Webservices API natively “reads” and writes MIAHA XML standard Cellomics Store database

  6. Current Standard Usage • Generation 2 Implementation • Evotec Opera • GeneData Screener • ArrayScan • CellWoRx • Generation 1 Implementation • INCELL 1000 • INCELL 3000 • Other custom

  7. HCSGateway™ Open Instrument interface - implements MIAHA Cellomics Reader Family GE IN Cell Analyzer 1000 API CellWoRx* Reader HCSGateway Open Interface for Instrumentation GE IN Cell Analyzer 3000 Other Instruments Evotec Opera

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