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Extracellular Molding of Invasive and Non-invasive Cancer Cells

Extracellular Molding of Invasive and Non-invasive Cancer Cells. Elizabeth Smith Mentor: Brandon Lutz Advisor: Dr. Michael Cho Program Director: Dr. Andreas Linninger RET, University of Illinois-Chicago NSF CBET EEC-0743068 June 30, 2011. Background. 1) Cells have different morphologies.

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Extracellular Molding of Invasive and Non-invasive Cancer Cells

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  1. Extracellular Molding of Invasive and Non-invasive Cancer Cells Elizabeth Smith Mentor: Brandon Lutz Advisor: Dr. Michael Cho Program Director: Dr. Andreas Linninger RET, University of Illinois-Chicago NSF CBET EEC-0743068 June 30, 2011

  2. Background 1) Cells have different morphologies NCM460 SW620 Non-Invasive Invasive Non-Invasive Invasive Breast Cancers Colon Cancers

  3. Osteocyte hMSC Adipocyte Background 2) Cells respond to extracellular topography Substrate topography differences Substrate rigidity differences

  4. Goals • Current • Provide a microscale mold of differing cell morphology to alter the morphology of the seeded cells • Future • Determine if the change in morphology leads to change in cell behavior

  5. Current Goal • Provide a microscale mold of differing cell morphology to alter the morphology of the seeded cells • Future • Determine if the change in morphology leads to change in cell behavior Noninvasive Cancer Cell Invasive Cancer Cell Glass Substrate PDMS Substrate

  6. Experimental Outline

  7. Expected Outcomes Grown on non-invasive molds become Invasive Cells Non-InvasiveCells Grown on invasive molds become

  8. Applications • Micro-scale texturing of… • Implant technology • Breast reconstruction, bone & tooth, etc. • On-site cancer suppression • Stent technology • Invasive cell “catcher”

  9. References Information • Curtis, A., & Wilkinson, C. (January 01, 1997). Topographical control of cells. Biomaterials, 18, 24, 1573. • Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (January 01, 2006). Matrix Elasticity Directs Stem Cell Lineage Specification. Cell, 126, 4, 677. • Lim, J. Y., & Donahue, H. J. (January 01, 2007). Cell Sensing and Response to Micro- and Nanostructured Surfaces Produced by Chemical and Topographic Patterning. Tissue Engineering, 13, 8, 1879-1891. Images • http://www.cardiolabel.com/stent%202.jpg • http://media.wiley.com/wires/WNAN/WNAN74/nfig007.jpg • http://www.genengnews.com/media/images/GENHighlight/Aug2_2010_FromPR_HumanMesenchymalStemCellGrowingOnMicroposts_NewInsightsonHowTheyBecomeTissues_crop1351984273.jpg • http://www.riverinahipandknee.com.au/Research.aspx

  10. Thank You

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