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Chemical Biology

Chemical Biology. Chem258, Spring 2009. Chem258: chemical biology. Instructor Martin Case, Cook A321 martin.case@uvm.edu Meeting times MWF 9:35 - 10:25 am, Angell 104 Class website http://www.uvm.edu/~mcase/courses/chem258. Course structure.

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Chemical Biology

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  1. Chemical Biology Chem258, Spring 2009

  2. Chem258: chemical biology • Instructor • Martin Case, Cook A321 • martin.case@uvm.edu • Meeting times • MWF 9:35 - 10:25 am, Angell 104 • Class website • http://www.uvm.edu/~mcase/courses/chem258

  3. Course structure • Based on student presentations (2 per student) • A paper that interests you • Extensive background not required • Powerpoint preferred • Hard copy for class to read and prepare for… • Discussion • 1-2 class periods • Be prepared to ask (and answer) questions • Instructor in the hot seat • Grading is based on presentations and participation in discussion sessions

  4. Time commitment • 3 credit class = 10 hours per week • 3 hours in class leaves 7 hours per week • 3 hours reading and researching other students’ presentations leaves 4 hours per week, 48 hours over the semester • 2 presentations per student over the course of the semester • Expect to spend about 24 hours on each presentation • 24 hours??? • 6 hours reading and researching your paper • 18 hours to prepare your presentation (it can easily take an hour per slide)

  5. What is chemical biology? • The application of synthetic chemical techniques and tools to the study and manipulation of biological systems

  6. What is chemical biology not? • Biochemistry • chemistry of biological systems • relatively few classes of reactions • mediated by enzymes • Bio-organic chemistry • extension of organic chemistry toward biology • eg synthesis of natural products

  7. Some basic principles • Chemoselectivity • Biologically inherent (thiols) • Exogenous via promiscuous systems (azido sugars, azidohomoalanine) • Molecular recognition • Stereocomplementarity • H-bonding • Hydrophobic interactions • Ultimately everything is aqueous

  8. Why does it matter? • Drugs • Modern medicinal chemistry (inhibitor design) is essentially chemical biology • Different drugs • Antibody therapeutics • Interference RNAs • Probes and diagnostics • Tumor cell labeling • Enzyme and metabolite tracking • 21st century medicine • Proteomics and glycobiology • Catalysis

  9. Chemical biology publications since 1990 record count year

  10. Chemical biology journals • Chemical Biology (ACS) • Nature Chemical Biology • Journal of Chemical Biology (Springer) • ChemBioChem • Chemistry & Biology • Chemical Biology (RSC) • chemical biology articles from RSC publishing

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