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Impact of Isoproterenol on Calcium Transients and SR Calcium Load in Cardiomyocytes

Study on the effect of Isoproterenol (Iso) on intracellular calcium levels and sarcoplasmic reticulum calcium load in cardiomyocytes. Results show significant alterations in [Ca2+]i transient and SR Ca2+ load with varying Iso concentrations and frequencies.

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Impact of Isoproterenol on Calcium Transients and SR Calcium Load in Cardiomyocytes

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  1. 3 Hz 2 Hz A WT R4496C 100 μm ISO ISO 250 ms 150 100 Iso effect on [Ca 2+]i transient (% F/F0 of control) 50 0 WT R4496C WT WT R4496C R4496C 4 Hz B 120 80 Iso effect on SR Ca 2+ load (% F/F0 of control) 40 0 WT R4496C WT WT R4496C R4496C 4 Hz 3 Hz 2 Hz

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