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PXN

VEGFA: miR-29abc; miR-15/ 16 /195/ 424 /497; miR-205; miR-200bc/429 ; miR-383; miR-140/140-5p/876-3p; miR-203; miR-199/199-5p; miR-503; miR-1/206; miR-17-5p/20 /93.mr/ 106 /519.d; miR-103/107; miR-106/302; miR-150; miR-24; miR-139-5p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699

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  1. VEGFA: miR-29abc; miR-15/16/195/424/497; miR-205;miR-200bc/429; miR-383; miR-140/140-5p/876-3p; miR-203; miR-199/199-5p; miR-503; miR-1/206; miR-17-5p/20/93.mr/106/519.d; miR-103/107; miR-106/302; miR-150; miR-24; miR-139-5p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699 VEGFB: miR-140/140-5p/876-3p; miR-101; miR-27ab; miR-125/351; miR-128; miR-375 VEGFC: miR-128; miR-27ab; miR-133; miR-101 VEGFA/B/C miR-200bc/429; miR-221/222; miR-455/455-5p; miR-138; miR-15/16/195/424/497; miR-338/338-3p; miR-23ab; miR-129/129-5p; miR-141/200a; miR-375; miR-214/761 VEGFR2 PLCG 1/2 SH2D2A miR-29abc; miR-1/206; miR-18ab; miR-137; miR-25/32/92/92ab/363/367; miR-129/129-5p; miR-27ab; miR-141/200a; miR-200bc/429; miR-31; miR-128 miR-203; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-141/200a; miR-137; miR-1/206; miR-31; miR-144; miR-153; miR-214/761;miR-184; miR-208/208ab; miR-22; miR-499/499-5p; miR-182; miR-10; miR-503; miR-9; miR-138; miR-24; miR-204/211; miR-218 miR-103/107; miR-24; miR-15/16/195/424/497 miR-200bc/429; miR-204/211; miR-135; miR-218; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-182; miR-101; miR-96/1271; miR-1/206; miR-125/351; miR-205; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-214/761; miR-129/129-5p; miR-155; miR-103/107; miR-455/455-5p; miR-223; miR-181 miR-9; miR-338/338-3p; miR-218; miR-146 FAK: miR-135; miR-138; miR-106/302; miR-196ab; miR-7/7ab; miR-221/222; miR-551ab; miR-145; miR-17-5p/20/93.mr/106/519.d; miR-199/199-5p; miR-139-5p; miR-25/32/92/92ab/363/367; miR-23ab Paxillin: miR-203; miR-145; miR-216/216b; miR-137; miR-199/199-5p; miR-132/212; miR-24; miR-27ab; miR-125/351; miR-140/140-5p/876-3p; miR-9; miR-218; miR-122; miR-128 IP3 DAG Ca2+ miR-203; miR-106/302; miR-10; miR-148/152; miR-155; miR-19; miR-124/506; miR-132/212; miR-124/506; miR-122; miR-203; miR-143; miR-142-3p; miR-25/32/92/92ab/363/367; miR-33/33ab; miR-129/129-5p; miR-24 * miR-33/33ab; miR-19; miR-124/506; miR-128; miR-23ab; miR-22; miR-125/351; miR-24; miR-27ab; miR-216/216b; miR-375; miR-143; miR-133; miR-146; miR-145; miR-141/200a; miR-214/761; miR-130/301; miR-10 CALN1: miR-143; miR-218; miR-25/32/92/92ab/363/367; miR-33/33ab; miR-138; miR-200bc/429; miR-153; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-130/301; miR-129/129-5p; miR-183; miR-191; miR-122; miR-214/761; miR-199/199-5p; miR-22; miR-137; miR-133; miR-128; miR-135; let-7/98; miR-144; miR-21/590-5p; miR-205; miR-155; miR-7/7ab; miR-187; miR-145; miR-19; miR-204/211; miR-106/302; miR-103/107; miR-223; miR-1/206; miR-150; miR-375; miR-193ab; miR-23ab; miR-217; miR-203; miR-125/351; miR-383; miR-182; miR-192/215; miR-216/216b; miR-499/499-5p; miR-208/208ab; miR-132/212; miR-17-5p/20/93.mr/106/519.d; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-15/16/195/424/497; miR-139-5p; miR-503; miR-338/338-3p; miR-216/216a; miR-9; miR-26ab/1297; miR-221/222 NFAT5: miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-17-5p/20/93.mr/106/519.d; miR-205; miR-181; miR-148/152; miR-217; miR-194; miR-1/206; miR-124/506; miR-21/590-5p; miR-33/33ab; miR-150; miR-146; miR-132/212; miR-29abc; miR-190; miR-15/16/195/424/497; miR-7/7ab; miR-216/216b; miR-25/32/92/92ab/363/367; miR-203; miR-365; miR-183; miR-103/107; miR-31; miR-143; miR-122; miR-27ab; miR-18ab; miR-140/140-5p/876-3p; miR-10; miR-24; miR-22; miR-128; miR-210; miR-221/222; miR-135; miR-155; miR-101; miR-133; miR-383; miR-139-5p; miR-153; miR-200bc/429; miR-216/216a; miR-129/129-5p; miR-138; miR-499/499-5p; miR-9; miR-204/211; miR-196ab; miR-192/215; miR-490/490-3p; miR-375; miR-338/338-3p; miR-141/200a SPHK1: miR-124/506; miR-1/206 SPHK2: miR-153; miR-130/301; miR-338/338-3p; miR-1/206; miR-19; miR-25/32/92/92ab/363/367; miR-184; miR-137; miR-181; miR-451; miR-503; miR-383; miR-15/16/195/424/497; miR-31 KRAS: miR-181; miR-27ab; miR-143; miR-217; miR-96/1271; miR-132/212; miR-155; miR-193ab; miR-19; miR-365; miR-199/199-5p; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-141/200a; miR-216/216b; miR-1/206; miR-425/489; miR-129/129-5p; miR-214/761; miR-146; miR-383; miR-190; miR-204/211; miR-23ab; miR-15/16/195/424/497; miR-200bc/429; miR-216/216a; miR-125/351; miR-128; miR-101; miR-218; miR-31; miR-144; miR-7/7ab; miR-194; miR-142-3p; miR-490/490-3p HRAS: miR-338/338-3p miR-137; miR-31; miR-9; miR-24; miR-7/7ab; miR-425/489; miR-19; miR-183; miR-150; miR-22; miR-125/351; miR-96/1271; miR-182; miR-214/761 miR-7/7ab; miR-19; miR-15/16/195/424/497; miR-125/351; miR-135; miR-455/455-5p; miR-503; miR-139-5p; miR-150; miR-1/206; miR-143 MAP2K1: miR-181; miR-15/16/195/424/497; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-148/152; miR-144; miR-96/1271; miR-130/301; miR-203; miR-503; miR-139-5p; miR-23ab MAP2K2: miR-503 miR-214/761 MAP2K 1/2 miR-204/211; miR-128; miR-132/212; miR-23ab; miR-150; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-27ab; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-190; miR-214/761; miR-10; miR-187; miR-29abc; miR-216/216a; miR-15/16/195/424/497; miR-122; miR-9; miR-125/351 miR-129/129-5p; miR-137; miR-96/1271; miR-22; miR-34a/34b-5p/34c/34c-5p/449/449abc/699 RAF1 RAS SPK PKC NFAT5 CALN1 FAK MAPK14 MAPK1 KAT5 PI3K CDC42 SRC SHC2 PXN HSPB2 MAPKAPK2

  2. * PRKCA: miR-205; miR-203; miR-199/199-5p; miR-23ab; miR-223; miR-219/219-5p; miR-139-5p; miR-17-5p/20/93.mr/106/519.d; miR-132/212; miR-150; miR-200bc/429;miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-129/129-5p; miR-216/216b; miR-375; miR-15/16/195/424/497; miR-216/216a; miR-22; miR-338/338-3p; miR-141/200a; miR-9; miR-24; miR-183; miR-1/206; miR-193ab; miR-210; miR-125/351; miR-214/761; miR-10; miR-503; miR-181; miR-122; miR-146; miR-138; miR-194; miR-204/211; miR-490/490-3p; miR-192/215; miR-217; miR-7/7ab PRKCB1: miR-183; miR-129/129-5p; miR-203; miR-141/200a; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-194; miR-182; miR-26ab/1297; miR-106/302; let-7/98; miR-365; miR-184; miR-148/152; miR-33/33ab; miR-29abc; miR-7/7ab PRKCD: miR-26ab/1297; miR-181; miR-129/129-5p; miR-490/490-3p; miR-218; miR-27ab; miR-15/16/195/424/497 PRKCG: miR-338/338-3p; miR-503; miR-140/140-5p/876-3p; miR-135; miR-1/206 PRKCE: miR-31; miR-96/1271; miR-129/129-5p; miR-216/216a; miR-101; miR-141/200a; miR-146; miR-205; miR-103/107; miR-1/206; miR-33/33ab; miR-182; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-143; miR-223; miR-10; miR-181; miR-383; miR-144; miR-23ab; miR-22; miR-21/590-5p; miR-132/212; miR-218; miR-216/216b; miR-25/32/92/92ab/363/367; miR-139-5p; miR-106/302; miR-125/351; miR-29abc; miR-19 PRKCH: miR-24; miR-205; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-216/216a; miR-204/211; miR-27ab; miR-17-5p/20/93.mr/106/519.d; miR-145; miR-383; miR-216/216b; miR-221/222; miR-200bc/429; miR-455/455-5p; miR-214/761 PRKCI: miR-203; miR-455/455-5p; miR-103/107; miR-219/219-5p; miR-146; miR-365; miR-10; miR-155; miR-183; miR-199/199-5p; miR-23ab; miR-141/200a;miR-204/211;miR-15/16/195/424/497;miR-129/129-5p;miR-24;miR-33/33ab;miR-200bc/429;miR-96/1271;miR-29abc;miR-1/206;miR-150;miR-490/490-3p;miR-217;miR-138;miR-18ab;miR-216/216a;miR-182;miR-181 PRKCQ: miR-26ab/1297; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-192/215; miR-25/32/92/92ab/363/367; miR-203; miR-183; miR-193ab; miR-221/222; miR-137; miR-31; miR-214/761; miR-383; miR-200bc/429 PRKCZ: miR-148/152; miR-15/16/195/424/497; miR-338/338-3p; miR-503 Supplemental Figure 3. Overview of VEGF signaling. Summary of VEGF signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in renal cell carcinoma are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplement Table 4.

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