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Relationship of biocide use to antibiotic resistance

. . It's A Question of Residues. Non-residues. ?. TriclosanQACsTriclocarban. BleachPeroxidesAlcohols. . Residues. Cross- and Co- Resistance(Biocides and antibiotics). . Target mutations Multidrug efflux systems Plasmids

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Relationship of biocide use to antibiotic resistance

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    7. Mutations in InhA confer triclosan resistance in Mycobacterium smegmatis Strain Selected InhA Relative MIC on* mutation (in 7H9 medium) Triclosan Isoniazid mc2155 (wt) -- none 1.0 1.0 MT 1 TRC M161V 6.3 8.5 MT 9 TRC M103T 6.3 1.2 MT 17 TRC A124V 5.8 2.0 mc2651 INH S94A 6.3 22.0 mc2155 -- none 6.3 >64 (p::inhA) *TRC = triclosan, INH = isoniazid McMurry et al, AAC 43:711, 1999.

    8. Efflux as a Common Mechanism of Biocide and Antibiotic Resistance

    16. Antibiotic susceptibility of MRSA and benzalkonium chloride resistant derivatives MIC (?g/ml) Antibiotic MRSA Parent BZ-R-1 BZ-R-2 Oxacillin 16 512 512 Cloxacillin 0.5 256 512 Moxalactam 64 256 1024 Flomoxef 8 128 128 Cefmetazole 8 128 64 Cephalothin 64 128 128 Ampicillin 16 32 32 Chloramphenicol 4 4 4 Ofloxacin 8 32 32 Tetracycline 128 128 128 Benzalkonium chloride 5 10 10 Akimitsu et al, AAC 43:3042, 1999.

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