Supple. Fig. 1. (Morimoto et al.)

1. ACGCGGGGACACTCGCTCATCATTCATTCACCTTCCGGCCTCCTCCTCCTCCTTTCTTCCTCCGTCCGTCCACCCCCAAGT 81 TTCGTTCTCCACCACTTCTCTTCTTTTCAGGAGAGAGTTCATCTCATCTCCTTCCTAGTTAGGGTTTCTTGGCCTTGTCTG 162 TTCTTGATTGGTCGATTCTCCGCGCAAATTATGGAGAAGTTCCCTAATCTTGGGGGAGGAGGAGGGAGCGGCAGCGGCAGC 243 M E K F P N L G G G G G S G S G S 17 AGCAGTGCATCCATGGCCTCCTTCTTGCAGCTCCCACCGCCCTCCGCGTCGTCGCCCTCGCCGGAGCTGGCCGGCGAGCAG 324 S S A S M A S F L Q L P P P S A S S P S P E L A G E Q 44 CACGGCTCGCGGCTCGCGTTGCAGCAGCTCCTGGCCGCCCCGCCGCCGTCGGCGCAGCAGCAGCGGCAGCGCAGGGAGATC 405 H G S R L A L Q Q L L A A P P P S A Q Q Q R Q R R E I 71 TCGCCGGCGGACGTCGCGACCATCAAGGCCAAGATCATGGCGCACCCCCTCTACTCGCCGCTCCTCGCCTCCTACCTGGAC 486 S P A D V A T I K A K I M A H P L Y S P L L A S Y L D 98 TGCCAGAAGGTCGGCGCCCCGCCGGAGGTGCTGGAGAGGCTCTCGGCCGTGGCGGCGAAGCTGGACGCCGGGCATGGCCGG 567 C Q K V G A P P E V L E R L S A V A A K L D A G H G R 125 GGGAAGCACGAGTCCCCGCGCCCCGACCCGGAGCTCGACCAGTTCATGGAGGCCTACTGCAACATGCTGGCCAAGTACAGG 648 G K H E S P R P D P E L D Q F M E A Y C N M L A K Y R 152 GAGGAGTTGGCGCGGCCGATCCAGGAGGCCACGGAGTTCTTCAAGAGCGTCGAGACGCAGCTCGATTCCATCACATTCACA 729 E E L A R P I Q E A T E F F K S V E T Q L D S I T F T 179 GACAGTACTAATTGCGAAGGCGCGGGGTCGTCCGAGGACGAGCTGGACACGAGCTGCGTGGAGGAGATCGACCCCAGCGCG 810 D S T N C E G A G S S E D E L D T S C V E E I D P S A 206 GAGGACAAGGAGCTGAAGCACCAGCTGCTGAGGAAATACGGCGGCTACGTGGGGAGCCTCCGCCAGGAGTTCTGCAAGCGG 891 E D K E L K H Q L L R K Y G G Y V G S L R Q E F C K R 233 CGGAAGAAGGGGAAGCTCCCCAAGGAGGCCCGCCAGAAGCTGCTGCACTGGTGGGAGCTGCACTCCAAGTGGCCGTACCCC 972 R K K G K L P K E A R Q K L L H W W E L H S K W P Y P 260 TCTGAGACGGAGAAGATCGCGCTGGCGGAGTCGACGGGGCTGGACCAGAAGCAGATCAACAACTGGTTCATCAACCAGAGG 1053 S E T E K I A L A E S T G L D Q K Q I N N W F I N Q R 287 AAGCGGCACTGGAAGCCGGCGCCGGAGGACATGCCCTTCTCCGTGATGGACGGCGGCGTGGGCGCGAGCTTCCTCCCCGCC 1134 K R H W K P A P E D M P F S V M D G G V G A S F L P A 314 CCGCAGGGCCCGGCGCTGTACATGGACAGGGCGCCGTTCATGGTGGACGGCATGTACCGCCTCGGGTCGTGAGGCCTCTCT 1215 P Q G P A L Y M D R A P F M V D G M Y R L G S * 337 CCCTTTCTCCATCGGACGGGGACTGCCGGCCGGTGCCGTCGGCGTGGTACGTAAGCTCCATGCATGGCAACGGCATGCGGC 1296 CGGTACGTAACGTACTTAGTCTGACGACGACTACTCAATATTATGTTCCTTCGGTAAATACTCCATATATATCTGCCGTTC 1377 ACGTTGAACAAGTCTGCCAAGTGCCAAGTAGGAATATATATATTCTTTCCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Supple. Fig. 1. (Morimoto et al.)

2. GACCCACAGGCAACAGCATCTCCCTCCC 28 CCATAGTCACTCTGAGTTGGGCTGGGTGAAGAGAAGAGAACGAATCATTCAGTTGAGATCTCTCCCCTCGCAATAATTTTG 109 GGCTCTCTCCCTCTATCTACCGAGTGTTCTTGATTCAGAGAGGCCAAGAACAGCGCAAGAACAGCATGGTGTAGTGGTGCC 190 TCTAGTGCATTATGAGGAGTGAGGAGGTGGGATGGGCGATGGCCTGTGGTGCAGGTGGTGCAGATGGAGATGAAGGAGAGA 271 M E M K E R 6 CAGCGGTGGCGGCCTGAGGAAGACGCCATCCTCCGCTCCTACGTCCGGCAGTATGGCCCCCGCGAGTGGAACCTGGTGGCG 352 Q R W R P E E D A I L R S Y V R Q Y G P R E W N L V A 33 CAGCGCATGAACGTGCCCCTCGACCGCGACGCCAAGTCCTGCCTCGAGCGCTGGAAGAACTACCTCCGCCCCGGCATCAAG 433 Q R M N V P L D R D A K S C L E R W K N Y L R P G I K 60 AAGGGCTCCCTCACCGACGACGAGCAGCGCCTCGTCATCCGCCTCCAGGCCAAGCACGGCAACAAGTGGAAGAAGATCGCC 514 K G S L T D D E Q R L V I R L Q A K H G N K W K K I A 87 GCCGAGGTGCCTGGCCGCACGGCGAAGCGGCTCGGCAAGTGGTGGGAGGTGTTCAAGGAGAAGCAGCAGCGGGAGATCAGG 595 A E V P G R T A K R L G K W W E V F K E K Q Q R E I R 114 GACAGCCGGAGGCCGCCGCCTGAGCCCAGCCCCGACGAGAGGGGGAGGTACGAGTGGCTGCTCGAGAACTTCGCCGAGAAG 676 D S R R P P P E P S P D E R G R Y E W L L E N F A E K 141 CTCGTCAAGGAGAGGCAGCAGGTGGGAGTGGGCGCCACGCCGCTGCACCACCACCTCATGGCGGCTCCCATGCTCCCGCCC 757 L V K E R Q Q V G V G A T P L H H H L M A A P M L P P 168 TGGATGTCGTCCACCGCCACCAACGGCGCGCCCGTCTCCCCGGCGCCACCGTCGCCGTCCGTGACGCTCAGCCTCGCCTCC 838 W M S S T A T N G A P V S P A P P S P S V T L S L A S 195 GCCGTCGTCCCGCCCCCGACCGCCGCGCCGTGGATGCAGCAGCAGATGGCGGAGGACGGCGCCGCGTTCGGGTTCGCTAGG 919 A V V P P P T A A P W M Q Q Q M A E D G A A F G F A R 222 CCGCCACCGGCGCCGGGCATGGTGGCGGATGCTCCTCAGGCAGCGCTGGCGGAGCTGGCCGAGTGCTGCAGGGAGCTGGAC 1000 P P P A P G M V A D A P Q A A L A E L A E C C R E L D 249 GAGGGGCACCGCGCGTGGGCCGCGCACCGGAAAGAGGCATCGTGGAGGCTGAAGCGCGTGGAGCTGCAACTGGAGTCGGAG 1081 E G H R A W A A H R K E A S W R L K R V E L Q L E S E 276 CGCGCGTGCCGGCGGCGCGAGGCCGCGGAGGAGTTCGAGGCCAAGATGCGAGCGCTGTGGGAGGAGCAGGCGGCCGCCGTG 1162 R A C R R R E A A E E F E A K M R A L W E E Q A A A V 303 GAGCGCCTCGAGGCGGAGTACCGGGAGAAGGTGGCCGGCCTCCGGCGTGATGCCGAGCTCAAGGAGCAGAAGATGGCGGAG 1243 E R L E A E Y R E K V A G L R R D A E L K E Q K M A E 330 CAGTGGGCCGCCAAGCACGCCCGCCTCACCAAGTTCCTCGAGCAGGTCGGCTCGTCGTGCCGCCGCTGGCCGCCCGGCGAG 1324 Q W A A K H A R L T K F L E Q V G S S C R R W P P G E 357 ATGAACGGCCGCTGACGGCGCGCCACCGGCCGCTTTCTTGCACGCGCAGCATCCAAACCTCAAGAAGACGATGGCATCGCA1405 M N G R * 361 TGCTTGTTCGTTGCACAACTTCTTTAGTTTTCTTCTCTTTTACAACTGTTGGAAGCTTCACTTCTCACTCTAGTCTAGCTG 1486 ATCAGAAAATGTAAGCCGTTGCTGCTGCTACTGCCTTAATTTCACTTCTTTTCGGCCTGTCAAAAAAAAAA Supple. Fig. 2. (Morimoto et al.)

3. (A) WRS1 MEK-FPNLGGGGGSGSGSSSA-------SMASFLQLPPPSASSPSPELAGEQHGSRLALQ 52 RS1 *DQS*G***A*A**S**G*NSKAAATAV*SS******LST*-**A------YY*AP***L 53 OSH15 *DQS*G*******A*GSGKA*--------AS******LST*AAATA-----YY*TP***- 46 WRS1 QLLAAPPPSAQQQRQRR------------------EISPADVATIKAKIMAHPLYSPLLA 94 RS1 HHA**A*S*S**HQ*QQHHH----HYARHGA----*M*A*E*EA*****V***Q**A*** 105 OSH15 HQA**AAGPS*YHGHGHPHHGGGHHHSKHGGAGGG***A*E*ES*********Q**A*** 106 WRS1 SYLDCQKVGAPPEVLERLSAVAAKLDAGHGRGKHESPRPDPELDQFMEAYCNMLAKYREE 154 RS1 A***********D*****T*M******-SAA*R**-**-***************V***** 162 OSH15 A*****************T*T******-RPP*R*D-A*-********************* 163 WRS1 LARPIQEATEFFKSVETQLDSIT----------------FTDSTNCEGAGSSEDELDTSC 198 RS1 *T***D**M**L*R**A***C*SGGG------GSSSARLSLADGKS**V*****DM*PNG 216 OSH15 *T***D**M**L*RV*S***T*AGGAHGG---GAGSARLLLADGKS*CV*****DM*PSG 220 WRS1 VE----EIDPSAEDKELKHQLLRKYGGYVGSLRQEFCKRRKKGKLPKEARQKLLHWWELH 254 RS1 R*NDPP****R*******Y***K**S**LS******S*KK******************** 276 OSH15 R*NEPP****R*******F***K**S**LS******S*KK******************** 280 WRS1 SKWPYPSETEKIALAESTGLDQKQINNWFINQRKRHWKPAPEDMPFSVMDGGVGASFLPA 314 RS1 Y**************************************S-*****-**ME*-----FHP 329 OSH15 Y**************************************S-*****-**ME*-----FHP 333 WRS1 PQGPALYMDRAPFMVDGMYRLGS 337 RS1 QNAA*****-G***R******** 351 OSH15 QNAA*****-G***A******** 355 (B) WRS2 MKERQRWRPEEDAILRSYVRQYGPREWNLVAQRMNVPLDRDAKSCLERWKNYLRP OsRS2*R*************LA**********S**S****R**H**************** RS2*************V**A**********H**S****VA****************** PHAN*************L**A**KE****D*H**T****K**N**************K* AS1*******SG****L**A****F*****H**SE***K**N**************K* PsPHAN1**D*****A****L**A**K**********S****T**N**************K* LePHAN*R******A****L**A*******K**P**S****T**N**************K* WRS2 GIKKGSLTDDEQRLVIRLQAKHGNKWKKIAAEVPGRTAKRLGKWWEVFKEKQ OsRS2**************************************************** RS2********EE****************************************** PHAN****E***QE**I***N**********************************K AS1********EE*********E******************************** PsPHAN1********EE**H***S***T**********Q******************** LePHAN ********E*******Q*********************************** Supple. Fig. 3. (Morimoto et al.)