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Gülden Olgun

Analysis of the Acute Renal Failure and Its Relationship With Creatinine and BUN Before and After the Coroner Artery Bypass Operation. Gülden Olgun. Problem Definition. Situtation of the non-renal patients after bypass surgery

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Gülden Olgun

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  1. Analysis of theAcuteRenalFailureandItsRelationshipWithCreatinineand BUN BeforeandAftertheCoronerArtery Bypass Operation Gülden Olgun

  2. Problem Definition • Situtation of the non-renal patients after bypass surgery • Increase in the serum creatinine concentration or azotemia(blood urea nitrogen[BUN])

  3. Outline • Problem Definition • Introduction • Feature Selection • Methodology for preop/postop • Analysis of the R-Project and Knime Results • Demo • Conclusion

  4. Acute Renal Failure • Abrupt or rapid decline in renal filtration function • Rise in serum creatinine concentration • Rise in blood urea nitrogen – BUN- concentration • Have high Potassium level

  5. Creatinine - BUN • Creatinine • Breakdown product of creatine • Normal results*: adults  W : 0.66 – 1.09 mg/dL M(<50 age): 0.84 – 1.25 mg/dL (>50 age): 0.81 – 1.44 mg/dL • BUN • Breakdown product of protein • Normal results*: adults  W- M : 7.9 – 21 mg/dL > 60 age : 8 – 23 mg/dL * http://merkezlab.erciyes.edu.tr/biyokimya/referans.htm

  6. Coronary Artery Bypass Graft • Reroute the blood flow through a new artery • Requires open-chest surgery • Increase the BUN, creatinine • Cause acute renal failure

  7. FeatureSelection(CardioDataset) • RenalFeatures • PreStatus5(70): Preop. acuterenalfailure • RenalYetmezlik(85) • Renal(751): renalfailure, requirement of dialysis • MortalitePrimerNeden12(842): Mortaliteduetorenalfailure • Bypass Features • PeriferikArterHastalık(92) • OperasyonGrup0(358): Coroner Bypass Surgery • CreatinineFeatures • SonPreopKreatinin(86)

  8. Feature Selection(Laboratuar dataset) • Dosya_No • Preoperatif/PostOperatif • BUN • Kreatinin • Urik_Asit • Sodyum • Potasyum

  9. Methodology • PreOperation: • 10 fold • DecisionTree • SVM • NaiveBayesLearner • PostOperation: • Bypass patients • SVM • DecisionTree • Non-bypass patients • SVM • DecisionTree

  10. Preprocess • Preprocess for preoperation • Use patients’ ids which occur in both dataset(cardio and lab) -> R project • Preprocess for post operation • Get ids of patients whose operation is bypass and non-bypass

  11. Knime(Preoperation) Decision tree for PreStatus5 (Acute Renal Failure before bypass surgery)

  12. R-Project(Preoperation) Decision tree for PreStatus5 (Acute Renal Failure before bypass surgery)

  13. R-Project 1) root 9739 476 False (0.0337817024 0.9511243454 0.0150939522) 2) SonPreopKreatinin< 2.5 9592 356 False (0.0342994162 0.9628857381 0.0028148457) 4) OperasyonGrup0= 353 158 False (0.4419263456 0.5524079320 0.0056657224) 8) SonPreopKreatinin< 1.5 348 157 False (0.4482758621 0.5488505747 0.0028735632) 16) RenalYetmezlik< -0.5 273 117 (0.5714285714 0.4285714286 0.0000000000) * 17) RenalYetmezlik>=-0.5 75 1 False (0.0000000000 0.9866666667 0.0133333333) * 9) SonPreopKreatinin>=1.5 5 1 False (0.0000000000 0.8000000000 0.2000000000) * 5) OperasyonGrup0=False,True 9239 198 False (0.0187249702 0.9785691092 0.0027059206) 10) RenalYetmezlik< 1.5 9207 178 False (0.0187900510 0.9806668839 0.0005430651) * 11) RenalYetmezlik>=1.5 32 12 True (0.0000000000 0.3750000000 0.6250000000) * 3) SonPreopKreatinin>=2.5 147 27 True (0.0000000000 0.1836734694 0.8163265306) *

  14. R-Project(Postoperation) Normal results: Sodyum  Adults: 136-146 BUN  Adults: 7,9 - 21

  15. Knime(Postoperation) • For Bypass Patients Normal Results: Potassium -> Adults: 3.5 – 5.1 mmol/L BUN  Adults: 7,9 - 21

  16. Knime(Postoperation) • For bypass Patients (without BUN)

  17. Knime • Preoperation:

  18. Knime • Postoperation

  19. Knime • For non-bypass patients

  20. BUN-Creatinine-Potassium-Sodium Bypass patients Non-bypas patients

  21. Conclusion • High correlation between OperasyonGrup0 and PreStatus5 • Sodium and BUN relation in bypass patients

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