Reactivity of IgG Antibodies to Glycolipids and Ganglioside Complexes in Acute Motor Axonal Neuropathy

DESCRIPTION

This study investigates the reactivity of serum IgG antibodies in a patient with acute motor axonal neuropathy (AMAN). Notably, IgG antibodies did not react with individual antigens but demonstrated significant reactivity with ganglioside complexes, including asialo-GM1 (GA1) and LM1, along with GM1b, GD1a, GD1b, GT1a, GT1b, and GQ1b. The enhanced reactivity is visually represented by darker shades in certain wells compared to control wells with no antigen added, highlighting the specificity of the antibody response.

Download

1 / 1

Mar 18, 2014

Télécharger la présentation

Reactivity of IgG Antibodies to Glycolipids and Ganglioside Complexes in Acute Motor Axonal Neuropathy

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

GaNAc- GD1a GQ1b GM1b GT1b GD1b GD1a GT1a GM1 GA1 LM1 Figure e-1. Reactivity of IgG antibodies to single glycolipid and to ganglioside complexes in a patient with acute motor axonal neuropathy. Serum IgG antibodies reacted with none of the single antigens but with gangliosidecomplexes of asialo-GM1 (GA1) and LM1, GM1b, GD1a, GD1b, GT1a, GT1b and GQ1b as well as complex of GM1/GT1a. This is visually demonstrated by the darker shade in these wells when compared to the other wells. The oblique dotted line runs through the control wells, which have no antigen added to them. LM1 GM1 GM1b GD1a GalNAc-GD1a GD1b GT1a GT1b GQ1b GA1

More Related