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Lipoprotein sınıflandırılması

%TG. %Chol. LPE. Şilomikron. 86. 3. Origin. VLDL. 55. 12. Pre- . IDL. 23. 29. Pre- /. LDL. 6. 42. . HDL. 3. 15. . Lp(a). (LDL). (LDL). Pre- . Lipoprotein sınıflandırılması. Tip. Buzdolabı. LPE. LPs. I. Pos, clear. Normal. TG (chylos). IIa. Neg, clear.

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Lipoprotein sınıflandırılması

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  1. %TG %Chol LPE Şilomikron 86 3 Origin VLDL 55 12 Pre- IDL 23 29 Pre-/ LDL 6 42  HDL 3 15  Lp(a) (LDL) (LDL) Pre- Lipoprotein sınıflandırılması

  2. Tip Buzdolabı LPE LPs I Pos, clear Normal TG (chylos) IIa Neg, clear   band LDL IIb Neg, cloudy  , pre-  LDL, VLDL III Occ., cloudy  pre-  Chol, TG, VLDL IV Neg, cloudy -2 VLDL V Pos, cloudy -2 VLDL Chylos Fredrickson sınıflandırması

  3. Lipoprotein Apolipoprotein(s) Chylomicron AI, B-48, CI, CII, CIII VLDL B-100, CI, CII, CIII, E IDL B-100, E LDL B-100 HDL AI, AII Lp(a) (a), B-100 Lp Apolipoprotein İçerikleri

  4. Stok solusyonu metanol içinde en az 6 saat karıştırılarak hazırlanır. Kullanmadan önce ışıktan korunmalı ve oda ısında saklanmalıdır. Çalışma solusyonu stok solusyonunun 0.1M/L olacak şekilde NaOH veya distile su ile karıştırılması ile hazırlanır.

  5. Dislipoproteinemiler • primer yada seconder nedenli • Seconder : liver disease, renal failure, diabetes, hypothyroidism, lipodystrophies, ilaçlar • Primer nedenli hyperlipidemi: • Artmış üretim • defektif oluşum • defektif sellüler alım • dengesiz atılım

  6. Dyslipoproteinemiler • Hyperchylomicronemia • LPL deficiency • Apo C-II deficiency

  7. Dyslipoproteinemiler • Hyperchylomicronemia • LPL deficiency • Apo C-II deficiency • Hyperbetalipoproteinemia • Overproduction of VLDL • Enhanced conversion of VLDL to LDL • LDL enriched with cholesteryl esters • Defective LDL structure • Decreased LDL receptors

  8. C,TG E B Hyperbetalipoproteinemiler Endothelium C,TG LPL C E B VLDL Hepatocyte B-100 receptors C • LDL Normal TG B LDL IDL

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