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Understanding Advanced Glycation End-products (AGEs) Sources & Reduction Strategies

Learn about the primary sources of AGEs, including exogenous sources like food and tobacco smoke, and endogenous sources from within the body. Discover how to reduce AGE consumption through dietary modifications and make healthier food choices to mitigate AGE-related health risks.

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Understanding Advanced Glycation End-products (AGEs) Sources & Reduction Strategies

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  1. Overview of advanced glycation end-products (AGEs)Part 3

  2. Primary Sources of Advanced Glycation End-products (AGEs)

  3. Primary Sources for AGEs Exogenous Sources: • Food, especially the browning technique that gives food the acquired flavor we enjoy • Achieved by cooking protein with sugar in the absence of water leading to the formation of AGEs • 30% of food borne AGEs are absorbed when ingested • Synthetic AGEs are added into foods by manufactures, especially processed or precooked foods

  4. Primary Sources for AGEs Tobacco smoke The combustion of various pre-AGEs in tobacco during smoking gives rise to reactive and toxic AGEs.

  5. Primary Sources for AGEs Fructose and galactose undergo glycation at about 10 times a higher rate than glucose

  6. Primary Sources for AGEs Endogenous Source: • Takes place within your body through normal metabolism • Most of the blood sugar goes to providing energy that your body needs • A small proportion of the blood sugar is glycated to form AGEs in patients with normal blood glucose • Formation of AGEs is accelerated in diabetic patients due to increased availability of glucose • Low glucose concentration will unhook the sugars from the amino groups to which they are attached; however, chronically high glucose concentrations will have the opposite effect

  7. Reducing or Negating the Effects of Advanced Glycation End-products (AGEs)

  8. Low AGE Diet • Dietary Modifications • Reduce intake of • Processed or precooked foods, such as boxed foods, frozen meals, etc • Full-fat dairy • Meat • Fried/oven-fried/broiled foods • Butter/Mayo/Cream Cheese

  9. Low AGE Diet • Increase intake of • Fish (not fried or breaded) • Vegetables • Fruit • Low-fat dairy • Legumes/Whole grains • Boiled/Poached/Stewed foods • Nuts

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