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This presentation provides an overview of long-term complications arising from diabetes, emphasizing their development over years and the importance of early glucose control and screening programs. Key complications include retinopathy, nephropathy, neuropathy, and peripheral vascular disease, which can lead to blindness, kidney failure, and heart issues. The role of co-morbid conditions such as thyroid dysfunction and coeliac disease in diabetic patients, alongside necessary screening methods, is also discussed to aid in effective management and prevention strategies.
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Programme Long-term complications 1 2 Co-morbid conditions
Slide no 4 Complications • Eyes (retinopathy) blindness • Also cataracts • Kidneys (nephropathy) kidney failure • Nerves (neuropathy) decreased pain perception • Blood vessels • Limbs peripheral vascular disease • Heart heart attacks • Brain strokes Amputations
Slide no 5 Long-term complications • Take years to develop • May occur in childhood • Glucose control (HbA1c) related to risk of complications • Early control in childhood important (metabolic memory) • Complications due to injury to blood vessels • Cause of mortality
Screening programmes Limited joint mobility (LJM)
Slide no 7 Neuropathy • Peripheral neuropathy • Painful neuritis • ‘Glove and sticking’ distribution • Loss of sensation • Reduced reflexes • Autonomic neuropathy • Alteration in gastric function (gastroparesis) • Bloating, decreased appetite, constipation, diarrhoea • Palpitations • Urinary retention
Slide no 8 Neuropathy screening • Symptoms • Neurological examination
Slide no 9 Nephropathy • Increase protein excretion • Small increase early microalbuminuria • Treatment can slow progression • Large amount of protein excretion macroalbuminuria or proteinuria • Can cause increased blood pressure • Kidney failure • Treatment is dialysis or transplant
Slide no 10 Nephropathy screening • Annual microalbumin tests • Start 5 years after diagnosis or at start of puberty • Monitor blood pressure • Treat microalbuminuria proteinuria and/or high blood pressure with medication • Improve control (i.e. decrease HbA1c)
Slide no 11 Retinopathy • Bleeding and new blood vessels in the eye • 5-10% chance of blindness • Rapid improvement of poor control can cause retinopathy to get worse • Screen from 5 years after diagnosis or at start of puberty • Eye examination • Retinoscopy • Fundus photography is better if available
Cataract / Retinal hemorrhage Slide no 12 Cataract Retinal hemorrhage
Retinal Microvascular Complications Proliferative retinopathy Normal retina
Slide no 18 Co-morbid conditions (1) • Not caused by diabetes • More common in children & adolescents with diabetes • Common genetic predisposition • Auto-immune disease • Often no clinical symptoms • Need laboratory screening
Slide no 19 Co-morbid conditions (2) • Thyroid dysfunction • Goitre, hypothyroidism, hyperthyroidism • Thyroid function tests, thyroid antibodies • Coeliac disease • Sensitivity to gluten bowel dysfunction • Often asymptomatic positive transglutaminase or endomysial or gliadin antibodies • Addisons disease • Unexplained decrease in insulin doses, hypoglycaemia, slow growth, fatigue, increased skin pigmentation • Refer for management
Slide no 20 Other issues • Osteopenia • Necrobiosis lipoidica diabeticorum • Itchy/painful hardened skin patches • Lipohypertrophy (if injection sites are not rotated correctly) • Lipoatrophy
Skin complications of insulin injections Lipohypertrophy Lipoatrophy
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