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FISIOLOGÍA DIGESTIVA (BCM II)

FISIOLOGÍA DIGESTIVA (BCM II). Clase 16- Páncreas. Dr. Michel Baró A. Major discoveries in pancreatic exocrine physiology. Physiologic function of the pancreas. Pancreatic exocrine secretion. sólido. líquido. Pancreatic control system. Overview of the pancreatic gland. Insulina Glucagón

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FISIOLOGÍA DIGESTIVA (BCM II)

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  1. FISIOLOGÍA DIGESTIVA (BCM II) Clase 16- Páncreas Dr. Michel Baró A.

  2. Major discoveries in pancreatic exocrine physiology

  3. Physiologic function of the pancreas

  4. Pancreatic exocrine secretion sólido líquido

  5. Pancreatic control system

  6. Overview of the pancreatic gland Insulina Glucagón Somatostatina Polipéptido pancreático 10% 10% 80%

  7. Electron micrographs of pancreatic acinar cells (a) RER Golgi Vacuolas Condensantes Gránulos Zimógeno Lumen (estímulo)

  8. Electron micrographs of pancreatic acinar cells (b)

  9. Overview of the neural innervation of the pancreas (sensorio-motor) T5 – T9 Neurotransmisores: ACTH VIP GRP Inerva:vasos sanguíneos Ganglios Fibras dolorosas + señales del Plexo mientérico

  10. Overview of the duodenum Aferentes vagales que responden a pH, aminoácidos, lípidos Expresan receptores de CCK y secretina. S I

  11. Feedback: control mechanisms

  12. Sensation and amplification

  13. Neurohormonal control of pancreatic bicarbonate secretion

  14. The vagus and bicarbonate secretion

  15. Cholecystokinin and pancreatic secretion -COOH Receptores CCK-A (alimentary) CCK-B (brain) (Tirosina Sulfatada en pos.7)

  16. Origin of cholecystokinin (a) Origen: Cel. Endocrinas intestinales (I) Neuronas SNC y SNE Neuronas del Páncreas lumen

  17. Origin of cholecystokinin (b) Lumen intestinal apical basal

  18. Actions of cholecystokinin Enzimas Bicarbonato

  19. Neurohormonal control of digestive enzyme secretion

  20. Cholecystokinin and pancreatic enzyme secretion

  21. Cholecystokinin receptors and afferent vagal fibers

  22. Modifying mechanism controlling pancreatic secretion amplificación

  23. Duodenal release of cholecystokinin

  24. Neurohormonal feedback system controlling enzyme secretion

  25. Most fundamental work came from work of Pavlov and students

  26. Inhibitory neuromodulators

  27. Role of inhibitory peptides and impairing their action +30-40% sin inhibidores

  28. Somatostatin inhibits pancreatic secretion

  29. The somatostatin receptor agonist, octreotide

  30. Pancreatitis aguda

  31. Etiologic classification of acute pancreatitis

  32. Obstructive causes of acute pancreatitis

  33. Toxins causing acute pancreatitis

  34. Drugs that can cause acute pancreatitis

  35. Metabolic causes of acute pancreatitis

  36. Inherited forms of acute pancreatitis

  37. Infectious causes of pancreatitis

  38. Vascular causes of pancreatitis

  39. Traumatic causes of acute pancreatitis

  40. Biliary drainage of idiopathic acute pancreatitis

  41. Summary of main etiologies for acute pancreatitis

  42. Pathogenetic sequence of acute pancreatitis

  43. Possible pathogenetic sequence of acute pancreatitis

  44. Pathology of acute interstitial pancreatitis

  45. Pathology of necrotizing pancreatitis

  46. Fat necrosis

  47. Pathology of necrotizing/hemorrhagic pancreatitis

  48. Diagnosis of acute pancreatitis

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