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Picornavirinae , Picornaviridae , Enterovirus PowerPoint Presentation
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Picornavirinae , Picornaviridae , Enterovirus

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Picornavirinae , Picornaviridae , Enterovirus

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Picornavirinae , Picornaviridae , Enterovirus

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  1. Picornavirinae, Picornaviridae, Enterovirus Order Family Genus Species HRV-A (75 types) HRV-B (25 types) HRV-C (48 types) Genotypesshare >87% VP1 protein identity (136x) Species share >70%VP1 protein identity

  2. HRV-C RNA in infected sinus mucosa Bochkov Y et al Nature Medicine (Apr10, 2011)

  3. The HRV-A and HRV-B use ICAM-1 (88x) or LDLR (11x) receptors HRV-14 x ICAM-1 High resolution structures and footprint maps exist for both types of receptor interactions

  4. 5x 5x 5x A16 1aym For all HRV-C every VP1 lacks 35 aarelative to HRV-B 21 aarelative to HRV-A All mass loss is at 5x B14 4rhv C15 model

  5. C15 model predicts the new "5x well" would be perfect fit for (e.g.) sialic acid HRV-C15 (model) HRV-B14 (4hrv)

  6. Chimera renderings: Shorter 5-fold vp1 loops make 5-fold well HRV-A16 (1ncr) HRV-C15 (Model #3)

  7. 5-fold close-up (radial depth-cue) HRV-A16 (1ncr) HRV-C15 (Model #3)

  8. Slice at 5-fold 5-fold 5-fold vp1 vp1 vp1 vp1 HRV-A16 (1ncr) HRV-C15 (Model #3)

  9. Antiviral drugs like pleconaril bind within a VP1 pocket and prevent protein rearrangements during uncoating C15 model 3-{3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy] phenyl}-5-(trifluoromethyl)-1,2,4-oxadiazole CHEMBL 29069

  10. A16 1ncr C15 drug binding pocket fits A16almost perfectly B14 1ncq Are HRV-C Type 2 drug group? C15 model A16 B14 C15 pleconaril