1 / 8

Mesenchymal Stem Cells | Dr. David Greene Arizona

Mesenchymal stem cells are multipotent adult stem cells found in a variety of organs such as the umbilical cord, bone marrow, and adipose tissue. Mesenchymal stem cells can divide and develop into a variety of tissues, including bone, cartilage, muscle, and fat cells, as well as connective tissue. In this presentation, Dr. David Greene Arizona discusses Mesenchymal Stem Cells & the Blood-Brain Barrier (BBB).

drdavidgreenearizona
Télécharger la présentation

Mesenchymal Stem Cells | Dr. David Greene Arizona

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Mesenchymal Stem Cells Dr. David Greene Arizona

  2. Mesenchymal Stem Cells & the Blood-Brain Barrier (BBB) Modern studies suggest that Mesenchymal stem cells (MSCs) when administered intravenously, can cross the blood-brain barrier (BBB) leading to various regenerative effects

  3. Do mesenchymal stem cells administered via IV cross the blood-brain barrier (BBB)? Mesenchymal stem cells (MSCs) intrinsically possess unique features that help them migrate towards areas of inflammation. MSCs secrete various types of secretomes to induce nerve regeneration and pain-relieving effects at inflammatory sites

  4. What is the blood-brain barrier? The blood-brain barrier (BBB) is a dispersion barrier, which prevents the entry of most compounds from the blood to the brain. According to Ballabh, the barrier is highly particular, meaning it only allows certain substances to cross from the bloodstream into the brain. This protects the brain from toxins that can potentially damage neurons

  5. Stem cells cross the blood-brain barrier in an animal stroke model Mesenchymal stem cells represent a great potential to reverse neuronal damage associated with CNS diseases such as Multiple Sclerosis, Parkinson's disease (PD), and Alzheimer's disease (AD)

  6. What makes mesenchymal stem cells (MSCs) so special? Mesenchymal stem cells (MSCs) are an especially attractive therapeutic agent due to their ease of isolation, established safety, and potential to target multiple pathways involved in neuronal regeneration. MSCs are widely used in the treatment of various diseases due to their self-renewable, differentiation, anti-inflammatory, and immunomodulatory properties. In-vitro (performed in a laboratory setting) and in-vivo (taking place in a living organism) studies have supported the understanding mechanisms, safety, and efficacy of MSC therapy in clinical applications

  7. Homing mechanisms of mesenchymal stem cells (MSCs) One of the key benefits of mesenchymal stem cells is their ability to target specific areas of concern due to their intrinsic homing capabilities. Mesenchymal stem cell homing, when administered systemically can be defined as exiting circulation and migrating to the injury site

  8. Thank You

More Related