R&D

1. R&D 2013 RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

2. R & D Types of Investigation Audit Are we doing this to an accepted standard? Contact the Audit dept. Service Evaluation How do we do this in the hospital at the moment? Contact R&D@wsh.nhs.uk Research What is the best way of doing this? Contact R&D@wsh.nhs.uk

3. 2013 West Suffolk Hospital is running 115 clinical trials open to new subjects or in follow-up. RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

4. Clinical Trials Phases I & II Phase I (safety and tolerability) trials which involve first human exposure to a therapeutic agent. Phase II clinical trials primarily are intended to demonstrate whether or not the new drug will provide any benefit and whether that benefit is sufficiently better than standard treatments to warrant further development. RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

5. Clinical Trials Phases III & IV • Phase III trial are randomized controlled, on large patient groups. They are aimed at being the definitive assessment of how effective the drug is, in comparison with current standard treatment. This is the kind of study that patients from this hospital are most often recruited into. • Phase IV trials involve the safety surveillance and ongoing technical support of a drug after it receives permission to be sold. RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

6. Research for Patient Benefit at West Suffolk Hospital The Research Question Where do patients prefer to have their intravenous cancer therapy? In their own home? In a General Practice? In hospital? The OUTREACH Trial: Dr M Moody RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

7. Medicinal Plants Senna alexandrina a source of senna R&D UNIT WEST SUFFOLK HOSPITAL

8. Cancer Research at West Suffolk Hospital The Research Question Chemotherapy How much and for how long? RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

9. Research at West Suffolk Hospital The Research Question The Genetic Analysis of Multiple Sclerosis Researcher Dr Paul Molyneux Sponsor: Cambridge University NHS Foundation Trust Funder: Wellcome Trust & National Institutes of Neurological Disorders & Stroke RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

10. WSH Clinical Trials Unit (CTU) • Investigation of a new blood gas and electrolyte analyser(pictured) in partnership with Sphere Medical • For use in ITU and Cardiac Surgery RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

11. WSH Clinical Trials Unit (CTU) • A new facility for use by the NHS & private sector • To enable early phase development of drugs & devices • The device pictured is a new silicon chip that is being studied here RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

12. Research at West Suffolk Hospital What is the best therapy for advanced or metastatic prostate cancer? The STAMPEDE trial Researcher Dr Cathryn Woodward Dept. of Oncology West Suffolk Hospital RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

13. I have revised the slides for next year and included two cheesy Christmas cards from R&D. Medicinal Plants Salix alba a source of Aspirin R&D UNIT WEST SUFFOLK HOSPITAL

14. Research at West Suffolk Hospital The Research Question What is the best treatment for primary thrombocythaemia? The PT1 trial Researcher Dr Chitnavis Dept. of Haematology West Suffolk Hospital RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

15. Research at West Suffolk Hospital Phase III Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to evaluate the efficacy and safety of Certolizumab Pegol in subjects with adult-onset active and progressive Psoriatic Arthritis Researcher Dr David O’Reilly Dept. of Rheumatology West Suffolk Hospital RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

16. Medicinal Plants Madagascar Periwinkle a source of Vincristine R&D UNIT WEST SUFFOLK HOSPITAL

17. Let R&D take the strain!Contact:R&D@wsh.nhs.uk01284 712 790 RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

18. Health Technology Devices (HTD) The Health Technology Devices Programme aims to stimulate and promote collaborative research that contributes towards the development of new technology which meets patient needs. The HTD programme focuses on supporting the development of new medical devices and healthcare technologies that are capable of exploitation by the healthcare industries. HTD Calls are invited and handled through the HTD web portal at: www.healthtechnologyportal.org.uk RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

19. Clostridium botulinum source of Botox R&D UNIT WEST SUFFOLK HOSPITAL

20. West Suffolk Hospital Research Aim To ensure that all patients and healthcare professionals from all areas of healthcare can take part in and benefit from clinical research RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

21. Funding Programmes • Programme Grants for Applied Research • Programme Development Grant • Funding Projects • Research for Patient Benefit (RfPB) • Research for Innovation Speculation and Creativity (RISC) • Invention for Innovation Programme (i4i) • HTA Clinical Trials • Health Technology Devices (HTD) RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

22. The First Clinical Trial in 1747 James Lind compared six treatments for scurvy (non-randomised open label) Two patients were given cider Two elixir vitriol Two vinegar Two sea water Two spices, garlic & mustard seeds Two oranges and lemons Only the sailors given the fruit recovered It took 40 years for the Admiralty to issue lemon juice to all ships RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

23. Research Grants Research for Innovation Speculation and Creativity (RISC) RISC is a response-mode funding programme established to provide research of direct benefit to users of the NHS in England. The RISC programme is for potentially paradigm-changing projects in Health Services and Public Health Research. http://www.nihr-ccf.org.uk/site/programmes/risc/default.cfm RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL

24. HTA Clinical Trials • The HTA programme commissions research in three different ways: 1. By advertising standard calls for research proposals that address specific topics 2. By advertising special calls for research proposals that address themed areas 3. By funding HTA clinical trials and evaluation studies that are proposed directly by researchers. http://www.hta.ac.uk/funding/index.shtml RESEARCH & DEVELOPMENT UNIT WEST SUFFOLK HOSPITAL