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Human Health and Environmental Toxicology

Human Health and Environmental Toxicology. Warm-up. What units are LD 50 and ED 50 measured in? m g of chemical dose/Kg of body weight. Endocrine system. Glands – organs that release substance to other parts of body Endocrine (ductless) Exocrine (duct)

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Human Health and Environmental Toxicology

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  1. Human Health and Environmental Toxicology

  2. Warm-up • What units are LD50and ED50 measured in? • mg of chemical dose/Kg of body weight

  3. Endocrine system • Glands – organs that release substance to other parts of body • Endocrine (ductless) • Exocrine (duct) • Endocrine glands secrete hormones into the bloodstream

  4. Endocrine disruptor • Chemicals that disturb the processes controlled by the endocrine system

  5. Approaches to Environmental Health

  6. Phthalates intro • http://higheredbcs.wiley.com/legacy/college/raven/0470118571/take_a_stand/ch07.html?newwindow=true • http://www.cosmeticsinfo.org/HBI/23/ • http://phthalates.americanchemistry.com/Phthalates-Basics • http://www.fda.gov/Cosmetics/ProductandIngredientSafety/SelectedCosmeticIngredients/ucm128250.htm • http://www.aoec.org/PEHSU/documents/bpa_patient_july_8_08.pdf (plastic safety pdf)

  7. Phthalates + • http://www.cbsnews.com/video/watch/?id=6512473n&tag=contentMain;contentBody • http://www.rsc.org/images/Phthalates08_tcm18-140737.pdf • http://phthalates.americanchemistry.com/Phthalates-Basics/Questions-Answers/Phthalates-and-Health-QA.html • http://www.cbsnews.com/8301-18560_162-6506892.html

  8. Phthalates - • http://environment.about.com/od/healthenvironment/a/phthalates.htm • http://www.urmc.rochester.edu/news/story/index.cfm?id=1405 • http://safecosmetics.org/article.php?id=222 (perfume) • http://safecosmetics.org/downloads/NotTooPretty_report.pdf • http://safecosmetics.org/downloads/A-Little-Prettier_Dec08.pdf • http://safecosmetics.org/article.php?id=368

  9. Evaluation cosmetics • http://www.green-organic-world.com/cosmetic-ingredients.html

  10. BPA intro • http://higheredbcs.wiley.com/legacy/college/raven/0470118571/take_a_stand/ch07.html?newwindow=true

  11. BPA + • http://www.bisphenol-a.org/index.html • http://www.bisphenol-a.org/about/bpa-myths/index.html • http://www.bisphenol-a.org/pdf/FactSheet-environmental.pdf • http://factsaboutbpa.org/is-bpa-safe/questions-answers • http://www.plasticsinfo.org/Functional-Nav/FAQs/Polycarbon-Plastic • http://plastics.americanchemistry.com/Product-Groups-and-Stats/PolycarbonateBPA-Global-Group/About-BPA.pdf

  12. BPA - • http://www.medicalnewstoday.com/articles/151156.php (BPA -) • http://www.thenewhomemaker.com/plastic-bottle-safety (plastic safety) • http://www.ehow.com/how_6023359_tell-plastic-bottle-contains-bpa.html (plastic safety 2) • http://www.aoec.org/PEHSU/documents/bpa_patient_july_8_08.pdf (plastic safety pdf)

  13. MSG intro • http://www.wisegeek.com/what-is-umami.htm • http://www.msgtruth.org/whatisit.htm

  14. MSG + • http://www.guardian.co.uk/lifeandstyle/2005/jul/10/foodanddrink.features3 • http://larryfields.hubpages.com/hub/Larrys-MSG-Obesity-Experiment

  15. MSG - • http://www.msgtruth.org/ • http://stevemark122000.hubpages.com/hub/What-is-MSG-and-Why-is-it-Bad-for-Your-Health • http://www.nerac.com/nerac_insights.php?category=articles&id=28

  16. Dihydrogen monoxide • Also known as DHMO • Should it be regulated, labeled as hazardous, or banned? • LD50 in rats – 90g/kg • One paperclip = 1 gram

  17. On September 12, 1999, US Air Forcebasic trainee Micah J. Schindler died of heat stroke, severely complicated by water intoxication, two days after becoming seriously ill during a 5.8 miles (9.3 km) march. The Air Force changed its recruit training procedures as a result.[13]

  18. On June 9, 2002, 4-year-old Cassandra Killpack of Springville, Utah died as a result of water intoxication when her parents forcefully fed her as much as one gallon (3.8 liters) of water in a short period while she was being disciplined. Her mother, JennetteKillpack, was convicted in 2005 of child abuse homicide.[14]

  19. On October 12, 2002, 3-year-old Rosita Gonzalez of Hollywood, Florida died of water intoxication when her babysitter Nancy Gayoso punished her by forcing her to drink three quarts (2.8 liters) of water in a four-hour period.[15][16]Gayoso was arrested and charged with murder in the first degree on March 10, 2003. After being declared incompetent to stand trial in 2004 and 2005,[17]Gayoso was found competent on March 26, 2007.

  20. In 2003, Walter Dean Jennings, a freshman history major at SUNY Plattsburgh, was pledging the Psi Epsilon Chi "when he was forced to drink urine, stay awake for days and consume vast amounts of alcohol during a 10-day initiation and hazing process." According to PressRepublican.com, "On his last night of pledging the unrecognized fraternity, the 18-year-old was forced to drink gallons of water through a funnel, which caused his brain to swell from water intoxication and ultimately resulted in his death." 11 members of the fraternity were charged with criminally negligent homicide[18]

  21. British actor Anthony Andrews survived a case of water intoxication in 2003. He was performing as Henry Higgins in a revival of the musical My Fair Lady at the time, and consumed up to eight litres of water a day. He was unconscious and in intensive care for three days.[26][27] • Jonathan Paul Dent, 29, became lost during a four-hour walk through Tasmania's Dial Range on April 19, 2011. He called his wife a number of times to say he was lost. Rescue crews found his body in bushland two days later. The coroner found that Mr Dent most likely died from exercise-associated hyponatremia (EAH), a condition caused by drinking too much fluid during prolonged exercise.[28]

  22. Homework • When you go grocery shopping, look for some of these toxins in the ingredients and share with the class. • Chapter 8 review questions • Next week, either chapter 7 or 8 or will collected

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