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Anatomy of the Immune system Lecture #7 IMMUNOLOGY (BIOL 40400-01)

Anatomy of the Immune system Lecture #7 IMMUNOLOGY (BIOL 40400-01) Instructional Objectives for Anatomy of the Immune System ; Students should be able to: Define Immunology Discuss what stem cells are and their significance to immunology

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Anatomy of the Immune system Lecture #7 IMMUNOLOGY (BIOL 40400-01)

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  1. Anatomy of the Immune system Lecture #7 • IMMUNOLOGY (BIOL 40400-01) • Instructional Objectives for Anatomy of the Immune System; Students should be able to: • Define Immunology • Discuss what stem cells are and their significance to immunology • Identify and discuss the significance of the “key” cells/organs/proteins of the immune system • Assigned reading: pages: 228-235; 245-253. The T-cell Maturation

  2. T-cell Need accessory molecules And co-receptors e.g. CD#; CD4; CD8 APC

  3. As maturing T-cells journey through the thymus there newly expressed T-cell receptors (TCR) interact with APCs. This activity results in a selection process. • The thymus will perform 2 selection processes: • 1. Positive selection: T-cells who’s new TCR binds to the MHC molecules on APCs with or without self antigens will be… • selected for keeping. This is called MHC restriction. • 2. Negative selection: T-cells that bind extremely tight (high-affinity) to APCs will be… • eliminated via apoptosis. This results in self tolerance. • At the end of positive and negative selection, T-cells that survive (~5% of the starting population) will be: • Self MHC restricted • Self tolerant

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