1 / 16

Angio (vaso)- protectors (Summary)

Medical University of Sofia, Faculty of Medicine Department of Pharmacology and Toxicology. Angio (vaso)- protectors (Summary). Assoc. Prof. Iv. Lambev E-mail: itlambev@mail.bg. I. Drugs improving capillary function (capillarotonic drugs) They reduce capillary fragility and

dusty
Télécharger la présentation

Angio (vaso)- protectors (Summary)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Medical University of Sofia, Faculty of Medicine Department of Pharmacology and Toxicology Angio (vaso)- protectors (Summary) Assoc. Prof. Iv. Lambev E-mail: itlambev@mail.bg

  2. I. Drugs improving capillary function • (capillarotonic drugs) • They reduce capillary fragility and • permeability and prevent basal edothelium • membranedamage. They act like antioxidants • and prevent vitamin C and adrenaline oxidation. • These drugs also inhibit lipid oxidation and • synthesis of active oxygen species.

  3. Drugs improving capillary function • Bioflavonoids: Diosmin • Hesperidin, Hyperoside, • Naringin,Quercetin, Rutin • Rutascorbin® (rutin/ascorbic acid) • Semisynthetic flavonoids: • Troxerutin® • Saponins: Escin (derived from Aesculus hippocastanum – Horse-chestnut) • Combinations: Peflavit C® Synthetic preparations: Calcium dobesilate (Doxium® – in retinopathy)

  4. Aesculus hippocastanum (Horse-chestnut)

  5. Bioflavonoids • Fr. Cynosbati • (Dog rose) • Hb. Hyperici • (St. John’s wort) • Fr. Crataegi • (Hawthorn) • Fruits of citrus

  6. Hb. Hyperici (St. John’s wort)

  7. Fr. Crataegi (Hawthorn)

  8. Drugs improving capillary function are indicated in haemorrhagic diathesis, skin and retinal haemorrhages, different forms of capillary dysfunctions, radiation disease, infections and allergic diseases, varicose veins, atherosclerosis, hypertension, rheumatism, hepatitis, glomerulonephritis, meno- and methrorrhagias, paradontosis, drug capillary dysfunctions (caused by NSAIDs, glucocorticoids, reserpine, anticoagulants, arsenic compounds, gold salts).

  9. Atherosclerotic gangrene of foot

  10. Warfarin necrosis of breast skin 5 days after intaking of warfarin

  11. II. VENOTONIC DRUGS Detralex®, Endotelon®, Phelobodia® Troxerutin (Troxevasin®) Detralex® (diosmin/hesperidine) improves capillary functions, has venotonic and antiexudative action too, due to inhibition of PGs release. It inhibits leukocyte adhesion and migration. Detralex enhances lymphatic flow and drainage.

  12. Detralex®.Itsvenotonic effects is due to the prolonged NA action. Detralex improves skin perfusion and rheological properties of the blood. It is effective in chronic venous insufficiency, venous ulcer, hemorrhoids. Dosage: 2 x 1 tablet daily.

  13. Endotelon®is a purified and • standardized extract of • of grape seeds, contains procyanidolic • oligomeres. It has endothelium • protective and venotonic effects. • Endotelon is prescribed p.o. in chronic • venous and lymphatic insufficiency.

  14. Varicose veins Varicose ulcer

  15. Troxerutin(trihydroxyethylrutin) • has venotonic, antiexudative and haemostatic • activity. It improves capillary function and • inhibits thrombocyte aggregation too. • Troxerutin is used in varicose ulcers, • chronic venous insufficiency, superficial • thrombophlebitis, haemorrhoids, phlebo- • sclerosis, muscle cramps, pain of traumatic • origin (sprain, luxation). It is administered • orally or locally, applied on the damaged • area (2% gel).

  16. III. Heparin-containing… ointments • (used in superficial thrombophlebitis • and varicose veins): • Heparoid®, Lioton®1000 gel • IV. Antihaemorrhoidal drugs • Detralex® (orally) • Doloproct® (fluocortolone/lidocaine): supp. • and ointment • Procto-Glyvenol® (tribenoside/lidocaie): supp. • Ultraproct®(fluocortolone/cinchocaine): supp. • and ointment

More Related