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Overview of Hyoscyamine 6β-Hydroxylase: Functions and Applications in Alkaloid Production

Hyoscyamine 6β-hydroxylase (H6H) is a bi-functional enzyme crucial in the biosynthesis of tropane alkaloids like hyoscyamine and scopolamine found in plants such as Atropa belladonna and Datura species. This enzyme first stimulates and then depresses the central nervous system, revealing its dual role as an anticholinergic agent. H6H also plays a significant role in antispasmodic actions on smooth muscle and exhibits powerful hypnotic effects while slowing heart rate. Understanding H6H expression in hairy root cultures is key for metabolic engineering aimed at enhanced alkaloid production.

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Overview of Hyoscyamine 6β-Hydroxylase: Functions and Applications in Alkaloid Production

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  1. Hyoscyamine 6b-hydroxylase (H6H) is bi-functional enzyme H6H H6H Hyoscyamine Scopolamine 6-hydroxyhyoscyamine

  2. -anticholinergic agent -first stimulates and then depresses the central nervous system -antispasmodic actions on smooth muscle Atropa belladonna Hyoscyamus albus Scopolia japonica Many Datura sp. Hyoscyamine Hyoscyamine 6-hydroxylase(H6H) 6-hydroxyhyoscyamine H6H Hyoscyamus niger Duboisia leichhardtii Datura sanguinea -anticholinergic agent -depresses the cerebral cortex -powerful hypnotic -slows the heart Scopolamine

  3. Metabolic Engineering of Hairy Roots for Tropane Alkaloid Production

  4. Time Courses of H6H Expression in Hairy Roots

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