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Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A

Learn about the Influenza A/H1N1 virus subtype, its characteristics, life cycle, and available vaccines and antiviral treatments. Explore how the virus enters cells, reproduces, and the importance of vaccination. Get insights on influenza drift, reassortment, and the role of neuraminidase inhibitors in treatment.

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Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A

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  1. Influenza A/H1N1 W. Rose 20091026 H1N1 is a subtype of influenza type A Influenza types B and C also exist but less common, less infectious, and drift less rapidly than type A Drift: gradual change in properties due to relatively rapid mutation rate (due to lack of proofreading of RNA polymerase product) Reassortment: combinations of genes from different viruses in a multiply-infected cell

  2. http://medicineworld.org/images/blogs/9-2006/influenza-virus-82101.jpghttp://medicineworld.org/images/blogs/9-2006/influenza-virus-82101.jpg • Parts of virus • Membrane with glycoproteinshemagglutinin (H), neuraminidase (N); ion channels (M2) • Capsid (protein shell) • Ribonucleoproteins (ssRNA, RNA polymerase, etc)

  3. Influenza A/H1N1 life cycle • http://www.xvivo.net/zirus-antivirotics-condensed/ • How it enters the cell • What it does there • How it reproduces

  4. Influenza Vaccines • Seasonal Flu Vaccine • Mix of two A types, one B type • Injectable: killed (inactivated) virus • Nasal spray: live attenuated • H1N1 2009 Flu Vaccine • Injectable: killed (inactivated) virus • Nasal spray: live attenuated • Antiviral treatment • Oseltamivir (Tamiflu), zanamivir (Relenza) : neuraminidase inhibitors, blocks viral budding from cell • Amantadine etc.: blocks M2 ion channel, thus preventing uncoating; resistance common

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