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DNA Polymerase γ B Processivity Factor

This study explores the structure and function of DNA Polymerase γB and its processivity factor, shedding light on their role in DNA replication and repair. Using the PDB ID: 1G5H, we examine the superpositioning with the GRS dimerization domain and the four-helix bundle of the DNA binding domain. Mutations within the DNA binding domain are modeled, and the potential DNA interactions are discussed. Phylogenetic analysis indicates that PolγB and Glycyl-tRNA synthetase evolved from early gene duplications. This work contributes to understanding the evolutionary origins of these enzymes.

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DNA Polymerase γ B Processivity Factor

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  1. DNA PolymeraseγB Processivity Factor Molecular Cell, Volume 7, Issue 1 , 1 January 2001, Pages 43-54 PDB ID:1G5H

  2. Superpositioning with GRS

  3. Dimerization domain

  4. Four helix-bundle

  5. DNA binding domain

  6. Mutation of DNA bind domain

  7. Modeling structure

  8. PCNA

  9. What kinds of DNA will bind to it?

  10. BLASTP 2.2.10

  11. Multiple sequences alignment

  12. Phylogenetic tree

  13. Conclusion • PolγB & Glycyl-tRNA synthetase diverged from early gene duplication • Suggest that eukaryotic Glycyl-tRNA synthetase is from Archaea, PolγB is from Bacterial Glycyl-tRNA synthetase.

  14. 多謝聆聽！

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