1 / 41

Anticonvulsant Pharmacokinetics

Anticonvulsant Pharmacokinetics. Dennis Mungall, Pharm.D. Director, Virtual Education, NTPD Associate Professor Pharmacy Practice Ohio State University College of Pharmacy. Absorption of Phenytoin. Phenytoin sodium is 92% phenytoin

elam
Télécharger la présentation

Anticonvulsant Pharmacokinetics

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Anticonvulsant Pharmacokinetics Dennis Mungall, Pharm.D. Director, Virtual Education, NTPD Associate Professor Pharmacy Practice Ohio State University College of Pharmacy

  2. Absorption of Phenytoin • Phenytoin sodium is 92% phenytoin • The time to peak is 3-12 hours after single dose of a capsule or tablet • Dilantin Kapseals are the only formulation that has absorption characteristics necessary for once daily dosing • Oral absorption fo Dilantin approaches 100%

  3. Oral preparations of Phenytoin

  4. Dose (mg) 400 800 1600 Peak Time ( hrs) 8.4 13.2 31.5 Time to Peak Cp

  5. Parenteral Administration of Phenytoin Gugler R et al . Clin Pharmac.Ther 1976; 135-42

  6. Distribution of Phenytoin • Following IV phenytoin distribution to tissues occurs in 30-60 minutes • Distribution to the brain is very rapid • The mean volume of distribution is comparable to total body water: 0.6-0.7 Liters/kg. • Phenytoin binds primarily to albumin, with approximately 10 percent of the drug normally unbound.

  7. Decreased In serum Albumin Burns Hepatic cirrhosis Nephrotic syndrome Pregnancy Cystic Fibrosis Decreased in affinity of binding to albumin Renal Failure Jaundice Other medications Conditions that lead to decreased protein binding of Phenytoin

  8. Adjustment of Total Phenytoin concentration for Albumin • Cnormal = Cobserved/(0.2*alb+0.1)

  9. Metabolism • Elimination of phenytoin occurs primarily by biotransformation to inactive hydroxylated metabolites. • The process of phenytoin elimination is saturable • Thus , increases in dose lead to disproportionate increases in phenytoin concentration

  10. Variation in Phenytoin Dose/cp Lund L. Bilogical Effects of Drugs. University Park Press 1972;227-39

  11. Demonstration of Dose/CP nonlinearity for Phenytoin Richens A., Dunlop A. Lancet 1975;2:247-48

  12. Steady State Concentration • Vmax= maximum rate of phenytoin metabolism in mg/day • Km: the concentration at which the rate of metabolism is half maximal ( mg/liter Css= Km-Dose(day)/Vmax-Dose(day)

  13. Saturation Pathway for Phenytoin

  14. Time to steady state based on dosing rate

  15. Time to 90% of SS as a function of Vmax and Km

  16. Equation for Time to 90% SS • T90% =(Km*Vd)/(Vm-Dose) * (2.3*Vm –0.9*Dose)

  17. Conditions Affection Phenytoin

  18. Clinical Response and Side Effects Kutt H et al. Arch Neurol 1964; 11:642-48

  19. Estimating the Loading Dose of Phenytoin • LD= Vd (C desired – C observed)/S*F • Where: Vd = volume of distribution ( 0.65L/kg) S=salt factor ( 0.92) F= fraction absorbed ( 1 ) Cdesired=10 to 20 mg/L Cobserved: if the patient is on phenytoin already and has a level prior to therapy

  20. Estimating Maintenance Dose • Mean Km for adults: 5.8 mg/L ( 0.1-27) and 5.3 mg/l for children Mean Vmax for adults:8mg/kg/day, children 12 mg/kg/day Dose/day= Vmax*Css/Km+Css

  21. Estimating Maintenance Dose Based on one SS Phenytoin CP Vozeh S et al . J Pharmacokinet Biopharm 1981;9:131-46

  22. Estimation of Dose based on two SS Phenytoin CP:Mullen Method Mullen RW. Clin Pharm Ther 1978;23:228-32

  23. Estimation of Dose based on two SS Phenytoin CP:Ludden Method Ludden TM et al . Clin Pharm Ther 1977;21:287-93

  24. Case Study #1 Mr SG is a 58 y/o, 72 inch, 70 kg male, seen recently with symptoms of a lower Respiratory infection. At this time he had a lesion noted on his Chest X-ray. A lung biopsy revealed a carcinoma with metastasis to The head , demonstrated via a CT scan. His albumin was 4 gm/l and serum creatinine 1.0 .Phenytoin therapy was initiated prohylactically at a dosage of 400 mg daily. Two weeksLater the patient had a grand mal seizure and the phenytoin Cp was5 mg/l. The dosage was increased to 500 mg qd and 3 weeks laterThe phenytoin concentration was 7 mg/l.

  25. Case # 1: Questions • Using the Ludden method graph and estimate the Vmax and Km for this patient. • Using this information , estimate a dose necessary to achieve a phenytoin concentration of 15 mg/l • Given the Vmax and Km estimate the timeto 90% of steady state • Estimate a Loading dose to achieve 15mg/l now.

  26. Case 1: Using DrugCalc • Using drugcalc, input the patient history , dosing history, and phenytoin history and model this • See how Vmax and Km compare with the Ludden method.

  27. Case 1 : Answers to Ludden Method

  28. Ludden Example • Y intercept=1225mg/day= Vmax • Slope=11.6mg/l= Km • Dose/day=Vmax xCp/Km+cp • Dose/day=1225x15/11.6+15 • Dose/day= 690mg phenytoin acid • Dose/day=750 mg phenytoin sodium

  29. Case 1 : Using Drugcalc • Input the patient dosage/cp history and estimate Vmax and Km • Using the Dosage calculator, estimate the dose to achieve a phenytoin concentration of 15 mg/L

  30. Screen # 1 : Input the name/age After inputing the name and age click on accept

  31. Choose phenytoin

  32. Select Edit Demographics

  33. Enter in the height , weight, serum albumin and serum creatinine When completed , click on accept

  34. Select inpatient dosing

  35. Insert Dose/Cp history Using the shortcut for multiple doses, 14s indicating 2 weeks , 21 s Indicating 3 weeks. D is for data ( concentration) . ( s for sustained release) Click on add after entering each line. When complete click on accept

  36. Choose Predict to Model : Select Parameters

  37. Review the Vmax, Km, Vd Click on done when finished

  38. Predicting SS dose • Using the new vmax and Km and the equation for dose, reestimate, by hand the dose of phenytoin necessary to achieve a ss concentration of 15 mg/l

  39. To Predict Dose, Select Predict and then Steady State

  40. Predicting SS dose

More Related