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This overview outlines the complex process of sperm fertilization, highlighting key aspects such as capacitation, the role of protective coatings, and the enzymatic actions that facilitate sperm movement through barriers like the corona radiata and zona pellucida. It describes how the sperm's acrosome reaction enables penetration of the oocyte, leading to the fusion of the sperm and oocyte nuclei, forming a diploid cell (zygote). Additionally, it explains the mechanisms preventing polyspermy and the completion of the second meiotic division in the oocyte.
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Fertilisation By Zoe Rees
FLAGELLUM MID-PIECE NUCLEUS HEAD PROTECTIVE COATING CORONA RADIATA PERIVETELLINE SPACE ZONA PELLUCIDA CELL MEMBRANE NUCLEUS
Capacitation The protective coating of PROTEINS and GLYCOPROTEINS is removed. This involves ENZYMES found in the uterus.
The sperm is travelling towards the egg, surrounded by the CORONA RADIATA, a membrane.
The enzymes DIGEST the ZONA PELLUCIDA surrounding the oocyte. The sperm contracts the CORONA RADIATA which ruptures releasing PROTEASE ENZYMES
INVERSION of the ACROSOME results in the formation of a NEEDLE-LIKE FILAMENT. The sperm travels through the CORONA RADIATA and ZONA PELLUCIDA and into the PERIVETELLINE SPACE.
The needle filament PIERCES the softened oocyte membrane, known as a ACROSOME REACTION. Allowing the head to penetrate. The entry of the head stimulates THICKENING of the ZONA PELLUCIDA which prevents the entry of other sperm known as POLYSPERMY.
The nuclei of the oocyte and the sperm FUSE together to form a DIPLOID CELL (ZYGOTE) The entry of the head stimulates the completion of the SECOND MEIOTIC DIVISION of the OOCYTE NUCLEUS.