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Evaluation of Immune Response in BAL Fluid with IL-4 and IFN-γ Levels

This study investigates the immune response in bronchoalveolar lavage (BAL) fluid by measuring cytokine levels of IL-4 and IFN-γ in control and treated groups. The concentrations of these cytokines are expressed in pg/ml, with specific comparisons made against total cell counts in BAL. Results show significant ratios of IL-4 to IFN-γ, indicating the type of immune response (Th2 vs Th1). The findings contribute to understanding the immune mechanisms involved in pulmonary responses to siNS1 treatment.

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Evaluation of Immune Response in BAL Fluid with IL-4 and IFN-γ Levels

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  1. control siNS1 20 IL-4 pg/ml 10 0 control siNS1 A 50  B 40 IFN- pg/ml 30 20 * 10 0 lung BAL supe D C 25 1.2 20 15 0.8 Total Cells in BAL (x10-3) Ratio, IL-4: IFN- 10 * 0.4 * 5 0 0 control siNS1 ephils lyms

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