Download
heparin binds plasma proteins angiomax bivalirudin binds specifically to thrombin n.
Skip this Video
Loading SlideShow in 5 Seconds..
Heparin Binds Plasma Proteins; Angiomax ® (bivalirudin) Binds Specifically to Thrombin PowerPoint Presentation
Download Presentation
Heparin Binds Plasma Proteins; Angiomax ® (bivalirudin) Binds Specifically to Thrombin

Heparin Binds Plasma Proteins; Angiomax ® (bivalirudin) Binds Specifically to Thrombin

113 Vues Download Presentation
Télécharger la présentation

Heparin Binds Plasma Proteins; Angiomax ® (bivalirudin) Binds Specifically to Thrombin

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. Heparin Binds Plasma Proteins; Angiomax® (bivalirudin) Binds Specifically to Thrombin Heparin (long strand) binds to other plasma proteins (colored molecules) and platelets, reducing heparin’s availability to bind to AT. Heparin-binding proteins are elevated in acute coronary syndromes (ACS). Angiomax (bright blue) binds onlyto thrombin (orange). Angiomax is not neutralized by other plasma proteins or platelets; it remains fully active near thrombus. Weitz JI et al. Thromb Res. 2002;106:V275-V284. Wittkowsky AK. Pharmacother. 2002;22(6 Pt 2):97S-104S. Hirsh J et al. Chest. 2001;119(1 suppl):64S-94S. CM Gibson 2006