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Ch 43

Ch 43. The Body’s Defense. Three lines of Defense:. 1. External defenses 2. Internal (phagocytes, inflammation) 3. Specific defense: (lymphocytes) 1 & 2 are non-specific, innate 3 is specific, acquired. Phagocytosis (WBC’s) non-specific.

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Ch 43

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  1. Ch 43 The Body’s Defense

  2. Three lines of Defense: • 1. External defenses • 2. Internal (phagocytes, inflammation) • 3. Specific defense: (lymphocytes) • 1 & 2 are non-specific, innate • 3 is specific, acquired

  3. Phagocytosis (WBC’s) non-specific • By Monocytes which turn into Macrophages (long-lived) • and also • neutrophils • Eosinophils • natural killer cells • Dendritic cells

  4. Inflammatory Response: non-specific • Basophils and Mast cells release histamines

  5. Other non-specific responses to infection: • Fever • Antimicrobial proteins • Interferons: inhibit viral reproduction

  6. What is specific immunity? • Pathogen, antigen, epitope (antibody generator) • Self vs. Non-self? • Blood groups (A, B, AB, O antigens) • Lymphocytes: (mature in thymus or bone marrow) • Helper T cells: TH • Cytotoxic T cells: Tc(enzymes, cell mediated immunity) • Suppressor T cells: Ts • B cells (antibodies, humoral immunity) • Memory B’s • Plasma cells

  7. http://video.google.com/videoplay?docid=-7586835408270491809&q=immune+response&total=1621&start=0&num=10&so=0&type=search&plindex=0http://video.google.com/videoplay?docid=-7586835408270491809&q=immune+response&total=1621&start=0&num=10&so=0&type=search&plindex=0

  8. Overview video ://video.google.com/videoplay?docid=-8860381196434790126&q=antibody+immune+response&total=44&start=0&num=10&so=0&type=search&plindex=1

  9. Immunological Memory: What is the second response like?

  10. Cell surface markers in T cell function • MHC (major histocompatibility complex) • “Self” Cell surface proteins, recognized by different T cells • Present the antigen to the T cells, initiates helper T cell responses

  11. Perforin,cell to cell attack

  12. Cytokine (Interleukins) and Helper T cells What is interleukin?

  13. Cytotoxic T cells, perforin • What is an APC? • Why does water rush in when a pore is created by perforin?

  14. Antigen driven cloning of lymphocytes: Clonal selection Effector B-cells Memory B-cellsMake antibodies

  15. Mechanisms of Humoral immunity: ANTIBODIES

  16. Antibody structure and function • Igs • HIV / AIDS • Active vs passive immunity • Vaccines • (pgs. 852-861)

  17. These are slides we did not use this year (2008)

  18. lymph nodes, bone marrow, thymus, spleen

  19. Most cells of the body: Macrophages, B cells, nucleated activated T cells, thymus CD8 CD4 Kills the infected cell Alerts B & T cells

  20. Perforin,cell to cell attack

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