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TAT (blue) gets into cells by inducing membrane pores and hijacking the cytoskeleton (green)

HIV TAT is a Swiss Army knife for getting into cells Gerard Wong, University of California-Los Angeles, DMR 1106106.

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TAT (blue) gets into cells by inducing membrane pores and hijacking the cytoskeleton (green)

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  1. HIV TAT is a Swiss Army knife for getting into cells Gerard Wong, University of California-Los Angeles, DMR 1106106 Cell penetrating peptides such as HIV TAT can get through cell membranes with high efficiency. Although these peptide sequences are used routinely in academia and industry, how they work is not well understood. We showed precisely how the HIV TAT sequence can induce pores in membranes and hijack the cytoskeleton of cells to gain entry. With this knowledge, we can reverse engineer these molecules for improved drug delivery and other applications. Other team members in this multidisciplinary collaboration include Tim Deming and Dan Kamei from UCLA, and JJ Cheng from the University of Illinois at Urbana-Champaign. The lead authors of this work are Abhijit Mishra (now an Assistant Professor in IIT Ghandinagar in India) and Ghee Hwee Lai (now a postdoc in native Singapore). TAT (blue) gets into cells by inducing membrane pores and hijacking the cytoskeleton (green)

  2. HIV TAT is a Swiss Army knife for getting into cells Gerard Wong, University of California-Los Angeles, DMR 1106106 Broader impacts: We started a outreach program at Mt Eden High School in Hayward, CA (the PI’s former high school), a city where both the income and rate of college matriculation are well below national averages. Our work is starting to attract the attention of industry: We were invited by Revalescio to an international workshop, and started a collaboration with a local antimicrobial company, C3 Jian. from your grant in the current year. We also started a number of international collaborations, including Berenike Maier in Cologne and Ramin Golestanian at Oxford. Dr. Wujing Xian explaining her experiments at UCLA to potential future scientists.

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