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Unrelated cord blood transplantation in Japan ； Japan cord blood bank network updated

Unrelated cord blood transplantation in Japan ； Japan cord blood bank network updated. Hideo Mugishima MD.,PhD Japan Pediatric Society Nihon-University School of Medicine Japan cord blood bank network. Paul Terasaki Festschrift UCLA Jan. 25 2014. 1982 ~ 1985.

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Unrelated cord blood transplantation in Japan ； Japan cord blood bank network updated

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  1. Unrelated cord blood transplantation inJapan；Japan cord blood bank network updated Hideo MugishimaMD.,PhD Japan Pediatric Society Nihon-University School of Medicine Japan cord blood bank network Paul Terasaki Festschrift UCLA Jan. 25 2014

  2. 1982~ 1985 UCLA

  3. UCLA (Terasaki Lab)1982-1983 • Human complement in the treatment of bone marrow cells • with monoclonal antibody (Lancet 2:1194-1195,1983) • Bone marrow from cadaver donors for transplantation (Blood 65 ：392-396, 1985)

  4. UCLA (Gale Lab)1983-1985 - In vitro hepatitisB virus infection of human bone marrow cells (J. Clin. Invest. 78： 411-417 1986)

  5. 1982~ 1985 UCLA During my research at UCLA, I had a wide variety of experiences.

  6. It was in 1989 when I read this paper regarding cord blood transplantation

  7. Background I Status of cord blood transplantation and banking in Japan Japan cord blood bank network Tokyo cord blood bank II Clinical outcome of cord blood transplantation in children in Japan

  8. History of Japan Cord Blood Bank Network ●1995.6 The first cord blood transplantation in Japan ● 1995.7 The first local bank was established ● 1997.5 Guidelines for cord blood transplantation were established ●1997.9 The Tokyo Cord Blood Bank was established ● 1998.1 The first meeting for cord blood transplantation was held ●1998.6 Technical guidelines for cord blood processing and transplant were established ● 1999.8 The Japan Cord Blood Bank Network was established (9 banks) ●2000.9 Public access to HLA typing from the Japan Cord Blood Bank Network ● 2001.12 Another local bank joined the Japan Cord Blood Bank Network(10 banks) ● 2002.7 Got ISO 9001 (Tokyo Cord Blood Bank) ● 2010.12 Done more than 1,000cases CBT in one year ● 2011.1 Started Intra Bone marrow CBT study (phase II trial) ● 2011.12 Reported Double CBT data (phase II trial study )

  9. Japan Cord Blood Bank Network RC Hokkaido Hyogo Cord Blood Bank RC Kanto&Koshinetsu RC Kyushu Tokai Univ. Cord Blood Bank Chubu Cord Blood Bank RC Kinki Tokyo Cord Blood Bank Japan Cord Blood Bank Network,2012

  10. No. of registered unit in each banks in Japan Cryopreserved Total ; 29,261 units/Japan 6,909 Tokyo Cord Blood Bank Tokai Uni CBB Hyogo CBB Chubu CBB Red Cross Kyushu Red Cross Kinki Red Cross Kanto& Koshinetsu Red Cross Hokkaido 1996～Aug. 2012.

  11. Local Bank Local Bank Local Bank Local Bank Local Bank Local Bank Local Bank Local Bank General Administration Office: Japanese Red Cross Society Agency of Auditing and Evaluation Ministry of Health, Labor and Welfare Japan Cord Blood Bank Network Japan Cord Blood Bank Network

  12. The number of cord blood transplants by age group(n=5,917) 1,200 1,000 1,466例 (24.0%) 800 (Cases) 600 400 200 0 5 ~ 9 0 ~ 4 20~29 30~39 40~49 50~59 60~69 70~89 10~14 15~19 (yrs)

  13. Background IStatus of cord blood transplantation and banking in Japan Japan cord blood bank network Tokyo cord blood bank II Clinical outcome of cord blood transplantation in children in Japan

  14. Overall survival in patients with ALL by disease status at cord blood transplant 1.0 0.75 0.5 0.25 0

  15. Overall survival in patients with AML by disease status at cord blood transplant 1.0 0.75 0.5 0.25 0

  16. Overall survival in patients with SCIDby stem cell source 1.0 0.75 0.5 0.25 0

  17. Overall survival in patients with WASby stem cell source 1.0 0.75 0.5 0.25 0

  18. Japan Cord Blood Bank Network Tokyo Cord Blood Bank Division of Cell Processing, Takahashi T., Nagamura-Inoue T., Kodo H.. Saito H., Kato, S., Kato, G., Takanashi, M., N, Hara H., Nihon University School of Medicine IYamamoto M.,Wada M., Chin M.,ShichinoH.,Yagasaki H Hematology/Oncology, Institute of Medical Science, Univ. of Tokyo Iseki T. Takahashi T. Asano S. Acknowledgement

  19. Thank you again for giving me the opportunity to present our experience. Dec.19.1982 July 26 1983

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