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GO Annotation: Strategies for Identifying Literature for Curation

GO Annotation: Strategies for Identifying Literature for Curation. Primary research literature with new experimental data - Mutant phenotypes – process - Activity assays – function - Localization studies – component 2. Computational analyses - Phylogenetic analysis – function (ISS)

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GO Annotation: Strategies for Identifying Literature for Curation

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  1. GO Annotation: Strategies for Identifying Literature for Curation • Primary research literature with new experimental data • - Mutant phenotypes – process • - Activity assays – function • - Localization studies – component • 2. Computational analyses • - Phylogenetic analysis – function (ISS) • - Domain analysis • 3. Review articles • - TAS evidence • 4. Meeting abstracts • - Accessible? • - Citing?

  2. GO Annotation: Sources of Literature for Curation • PubMed • - National Library of Medicine, National Institutes of Health • - http://ncbi.nlm.nih.gov • 2. Agricola • - United States Department of Agriculture, National • Agricultural Library • - http://agricola.nal.usda.gov • 3. Embase • - Elsevier • - http://www.embase.com • 4. Biosis • - Thomson • - http://www.biosis.org

  3. GO Annotations: What to Search For? 1. Gene/gene product names: daf-12, spo11, Sonic hedgehog 2. Process AND species: embryonic development AND elegans 3. Function AND species: transcription factor AND mays 4. Cellular component AND species (genus): plasma membrane AND Drosophila

  4. GO Annotation: GMOD Tools for Enhancing Information Retrieval GMOD – Generic Software Components for Model Organism Databases - http://www.gmod.org/home - Literature curation downloads: PubSearch – http://www.gmod.org/?q=node/44 PubFetch - http://www.gmod.org/?q=node/84 Textpresso – http://www.textpresso.org - full text of articles - semantic categories

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