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NH2

390. 1. 30. 279. NH2. COOH. Pre-pro-TGF- b 1. Signal Peptide. NH2. COOH. Pro-TGF- b 1. LAP. TGF b 1. endopeptidase. Active TGF- b 1. LTBP. SLC. LLC. Secretion. Release. Figure 1. Smad2/3. Smad2/3. TGF- b. SARA. Cytoplasm. II. I. I. FKBP12. Smad2/3. Smad7. Smad7.

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NH2

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  1. 390 1 30 279 NH2 COOH Pre-pro-TGF-b1 Signal Peptide NH2 COOH Pro-TGF-b1 LAP TGFb1 endopeptidase Active TGF-b1 LTBP SLC LLC Secretion Release Figure 1

  2. Smad2/3 Smad2/3 TGF-b SARA Cytoplasm II I I FKBP12 Smad2/3 Smad7 Smad7 Receptor Degradation Smurf1/2 Smad2/3 Microtubules Smad4 Smad4 Co-R Co-A Smad4 Nucleus Figure 2

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